Berman J J, Seidman J D, Yetter R, Moore G W
Laboratory Service, Baltimore Veterans Affairs Medical Center, Maryland 21218.
Anal Quant Cytol Histol. 1991 Dec;13(6):391-4.
Clear cell dysplasia of the bladder is a well-described morphologic entity that has been found in association with transitional cell carcinoma of the bladder. Its biologic role in bladder tumorigenesis is unknown, and no instances of its polidy analysis have been reported. The authors describe a case of clear cell dysplasia of the bladder found in association with a primary adenocarcinoma of the bladder. Flow cytometric analysis of bladder tissue involved by clear cell dysplasia, adenocarcinoma and cystitis cystica (all from the same bladder) demonstrated no DNA aneuploid populations. Cells from the area of clear cell dysplasia had an S + G2 + M fraction of 7%, indicating that it was a proliferative lesion. Cells from the adenocarcinoma had an S + G2 + M phase of 18%, and cells from an area of cystitis cystica had an S + G2 + M phase of 4%.
膀胱透明细胞发育异常是一种已被充分描述的形态学实体，与膀胱移行细胞癌相关。其在膀胱肿瘤发生中的生物学作用尚不清楚，且未报道过其倍体分析的实例。作者描述了一例与原发性膀胱腺癌相关的膀胱透明细胞发育异常病例。对由透明细胞发育异常、腺癌和囊性膀胱炎累及的膀胱组织（均来自同一膀胱）进行流式细胞术分析，未发现DNA非整倍体群体。来自透明细胞发育异常区域的细胞S + G2 + M期比例为7%，表明它是一个增殖性病变。来自腺癌的细胞S + G2 + M期为18%，来自囊性膀胱炎区域的细胞S + G2 + M期为4%。
