Davis Susan R, Shah Sonal M, McKenzie Dean P, Kulkarni Jayashri, Davison Sonia L, Bell Robin J
Women's Health Program, Department of Medicine, Monash Medical School, Central and Eastern Clinical School, Monash University, Alfred Hospital, Commercial Road, Prahran, Victoria 3181, Australia.
J Clin Endocrinol Metab. 2008 Mar;93(3):801-8. doi: 10.1210/jc.2007-2128. Epub 2007 Dec 11.
It has been proposed that dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function is lacking.
The objective of the study was to investigate whether circulating levels of DHEAS independently contribute to aspects of cognitive function in women in the community.
This was a community-based, cross-sectional study.
Two hundred ninety-five women, aged 21-77 yr, were recruited from a community-based data set and participated between September 2003 and December 2004. Women were excluded if they reported any health condition that might potentially adversely affect cognitive function.
The individual scores of a comprehensive battery of tests of cognitive function and the serum level of DHEAS (square root transformed) were measured.
In the multiple linear regression analysis, the DHEAS term made a significant independent positive contribution to the Controlled Oral Word Association Test score, a measure of executive function. In addition, women with a DHEAS level in the highest tertile who also had more than 12 yr of education performed better on both Digit Span Forward and Digit Span Backward tests, which are tests of simple concentration and working memory, respectively.
Higher endogenous DHEAS levels are independently and favorably associated with executive function, concentration, and working memory.
有人提出脱氢表雄酮和硫酸脱氢表雄酮（DHEAS）对大脑具有神经保护作用，但缺乏这些类固醇的内源性水平与认知功能指标之间关联的证据。
本研究的目的是调查社区女性中DHEAS的循环水平是否独立地对认知功能的各个方面有影响。
这是一项基于社区的横断面研究。
从一个基于社区的数据集招募了295名年龄在21 - 77岁之间的女性，她们在2003年9月至2004年12月期间参与研究。如果女性报告有任何可能对认知功能产生潜在不利影响的健康状况，则将其排除。
测量了一系列全面的认知功能测试的个体得分以及DHEAS的血清水平（平方根转换）。
在多元线性回归分析中，DHEAS项对控制口语单词联想测试得分（执行功能的一项指标）有显著的独立正向贡献。此外，DHEAS水平处于最高三分位数且受教育年限超过12年的女性，在数字广度顺背和数字广度倒背测试中表现更好，这两项测试分别是简单注意力和工作记忆的测试。
较高的内源性DHEAS水平与执行功能、注意力和工作记忆独立且呈正相关。
