Dussan Carlos, Zubor Pavol, Fernandez Manuel, Yabar Alejandro, Szunyogh Norbert, Visnovsky Jozef
Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Martin, Slovakia.
Gynecol Obstet Invest. 2008;65(3):206-11. doi: 10.1159/000112228. Epub 2007 Dec 10.
Spontaneous regression of malignant tumors is a rare event. It is defined as partial or total disappearance of a proven malignant tumor without adequate medical treatment. The causes of this phenomenon are various. Nevertheless, malignant tumors do regress occasionally for no apparent reason, as evidenced by many clinical observations. We report a case of a 68-year-old woman, who was presented with a several-month history of a painless firm lump, initially of 1 cm in diameter and growing to a large solid regular tumor of 2.5 x 2.5 cm in size, in the upper outer quadrant of her right breast. Preoperative histopathological diagnosis revealed ductal invasive carcinoma. Later on, while awaiting surgical treatment, she suffered an arm injury requiring a 1-month delay of surgery. After recovery, on the date of surgery the tumor disappeared, and, in addition, it was not found in tissue specimens obtained from quadrantectomy. After 78 months of follow-up there was no evidence of relapse. In this report, we discuss clinical and histopathological findings, patient management and possible mechanisms of cancer regression.
恶性肿瘤的自发消退是一种罕见事件。它被定义为经证实的恶性肿瘤在未接受充分医学治疗的情况下部分或完全消失。这种现象的原因多种多样。然而，正如许多临床观察所证明的，恶性肿瘤偶尔会毫无明显原因地消退。我们报告一例68岁女性病例，她有一个无痛性坚实肿块，已有数月病史，最初直径为1厘米，后来发展为右乳外上象限一个大小为2.5×2.5厘米的大型实性规则肿瘤。术前组织病理学诊断为导管浸润癌。后来，在等待手术治疗期间，她手臂受伤，手术推迟了1个月。康复后，手术当天肿瘤消失，此外，在象限切除术中获取的组织标本中也未发现肿瘤。经过78个月的随访，没有复发迹象。在本报告中，我们讨论了临床和组织病理学发现、患者管理以及癌症消退的可能机制。
