Albin Roger L, Koeppe Robert A, Bohnen Nicolaas I, Wernette Kristine, Kilbourn Michael A, Frey Kirk A
Geriatrics Research, Education, and Clinical Center, Ann Arbor VA, Ann Arbor, MI, USA.
J Cereb Blood Flow Metab. 2008 Mar;28(3):441-4. doi: 10.1038/sj.jcbfm.9600599. Epub 2007 Dec 12.
Postmortem data indicate loss of serotoninergic neurons in Parkinson's disease (PD). We used the serotonin transporter (SERT) radioligand 3-amino-4-(2-dimethylaminomethyl-phenylsulfaryl)-benzonitril (DASB) and positron emission tomography to examine SERT distribution and changes in early PD subjects. We studied five PD subjects (H&Y 1 to 2.5) and eight normal controls. There is reduced SERT binding in PD. The magnitude of DASB binding reductions was greater in the forebrain than in the brainstem regions. There was no asymmetry of diminished SERT binding. DASB binding in the medulla was relatively spared, inconsistent with the description of early prominent pathologic study in these caudal brainstem nuclei.
尸检数据表明帕金森病（PD）中5-羟色胺能神经元缺失。我们使用5-羟色胺转运体（SERT）放射性配体3-氨基-4-（2-二甲基氨基甲基-苯硫基）-苄腈（DASB）和正电子发射断层扫描来检查早期PD患者的SERT分布及变化。我们研究了5名PD患者（H&Y分级为1至2.5级）和8名正常对照者。PD患者中SERT结合减少。DASB结合减少的程度在前脑比脑干区域更大。SERT结合减少没有不对称性。延髓中的DASB结合相对保留，这与这些尾侧脑干核早期显著病理研究的描述不一致。
