Divisions of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN.
J Clin Lipidol. 2007 Jul;1(3):218-24. doi: 10.1016/j.jacl.2007.05.001.
Hypertensive African Americans have higher rates of coronary heart disease (CHD) than their non-Hispanic white counterparts despite having higher HDL cholesterol (HDL-C) levels and lower triglyceride levels.
The goal of the present study was to assess whether low-density lipoprotein (LDL) particle size, a correlate of the above lipid traits and a risk factor for CHD, differs between hypertensive African Americans and whites.
Participants included 1177 hypertensive African Americans from Jackson MS (60+/-7 years, 72.4% women) and 860 hypertensive whites from Rochester MN (58+/-7 years, 56.7% women). LDL particle size was measured by polyacrylamide gradient gel electrophoresis. Within each sex, we assessed whether ethnicity was significantly associated with differences in LDL particle size after adjustment for CHD risk factors (age, total cholesterol, HDL-C, triglycerides, systolic BP, diabetes, history of smoking, body mass index), statin use, and estrogen use (in women), and "lifestyle" variables (physical activity and alcohol intake).
Although HDL-C levels were higher and triglyceride levels lower in African Americans, LDL particle size (adjusted for CHD risk factors) was lower (P < 0.0001) in African American men and women than in their white counterparts (mean +/- SD; men, 267.6+/-5.2 A vs. 270.2+/-4.8 A; women 268.7+/-5.1 A vs. 271.3+/-5.1 A). In both sexes, African American ethnicity was associated with lower LDL particle size after adjustment for CHD risk factors, statin use and estrogen use (in women), as well as physical activity and alcohol intake.
Hypertensive African American men and women have lower LDL particle size than their white counterparts despite having higher HDL-C and lower triglycerides.
尽管高血压非裔美国人的高密度脂蛋白胆固醇（HDL-C）水平较高，且甘油三酯水平较低，但他们患冠心病（CHD）的比率却高于非西班牙裔白人。
本研究旨在评估低密度脂蛋白（LDL）颗粒大小是否存在差异，LDL 颗粒大小与上述血脂特征相关，是 CHD 的一个危险因素，而这种差异在高血压非裔美国人和白人中是否存在。
参与者包括来自密西西比州杰克逊的 1177 名高血压非裔美国人（60+/-7 岁，72.4%为女性）和来自明尼苏达州罗彻斯特的 860 名高血压白人（58+/-7 岁，56.7%为女性）。采用聚丙烯酰胺梯度凝胶电泳法测定 LDL 颗粒大小。在每个性别中，我们评估了在调整 CHD 危险因素（年龄、总胆固醇、HDL-C、甘油三酯、收缩压、糖尿病、吸烟史、体重指数）、他汀类药物使用和雌激素使用（女性）以及“生活方式”变量（体力活动和饮酒量）后，种族是否与 LDL 颗粒大小的差异显著相关。
尽管非裔美国人的 HDL-C 水平较高，甘油三酯水平较低，但非裔美国男性和女性的 LDL 颗粒大小（经 CHD 危险因素调整后）均低于其白人对照组（平均值+/-标准差；男性为 267.6+/-5.2 A 与 270.2+/-4.8 A；女性为 268.7+/-5.1 A 与 271.3+/-5.1 A）。在两性中，在调整 CHD 危险因素、他汀类药物使用和雌激素使用（女性）以及体力活动和饮酒量后，非裔美国人的种族与 LDL 颗粒大小较低相关。
尽管高血压非裔美国男性和女性的 HDL-C 水平较高，且甘油三酯水平较低，但他们的 LDL 颗粒大小仍低于其白人对照组。
