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[尼古丁对神经发育的影响]

[Effects of nicotine on neurodevelopment].

作者信息

Wessels C, Winterer G

机构信息

Psychiatrische Klinik, Heinrich-Heine-Universität, 40629, Düsseldorf.

出版信息

Nervenarzt. 2008 Jan;79(1):7-8, 10-2, 14-6. doi: 10.1007/s00115-007-2392-z.

Abstract

Nicotine exposure during prenatal to adolescent neurodevelopment causes morphologic changes in the CNS and persistent alterations of neurotransmission systems. Maternal smoking on the one hand and nicotine dependency and attention deficit hyperactivity disorder in the offspring on the other are significantly associated. There is even evidence that nicotine abuse during adolescence may result in deficits of the brain's attentional network. In contrast, any effects of nicotine exposure on the development of various psychiatric diseases are still unclear. The somatic consequences of smoking and the resulting economic problems are already well known, but the effects of nicotine on neurodevelopment are still underestimated. More public awareness training and medical education are required to avoid nicotine abuse in pregnant women, children, and adolescents.

摘要

从产前到青少年神经发育阶段接触尼古丁会导致中枢神经系统发生形态变化,并使神经传递系统发生持续性改变。一方面,母亲吸烟与另一方面后代的尼古丁依赖和注意力缺陷多动障碍之间存在显著关联。甚至有证据表明,青少年时期滥用尼古丁可能导致大脑注意力网络功能缺陷。相比之下,尼古丁暴露对各种精神疾病发展的任何影响仍不明确。吸烟的躯体后果及其导致的经济问题已广为人知,但尼古丁对神经发育的影响仍被低估。需要开展更多公众意识培训和医学教育,以避免孕妇、儿童和青少年滥用尼古丁。

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