Dorofeev I Iu, Avelev V D, Shcherbakova N A, Gerasimenko Iu P
Ross Fiziol Zh Im I M Sechenova. 2007 Oct;93(10):1112-22.
The role of hindpaw skin afferent input in the locomotor pattern formation induced by epidural spinal cord stimulation was investigated in decerebrated cats. Locomotor activity was evoked by continuous 3-5Hz stimulation of dorsal surface of L4-L5 spinal segments. Kinematic and electromyographic activity (EMG) of m. Quadriceps, m. Semitendinosus, m. Tibialis anterior an m. Gastrocnemius lateralis before and after blocking of skin receptors in one hind limb were recorded. In addition, reflex responses in the hind limb muscles to epidural stimulation with frequency 0.5 Hz were analysed. Blocking of skin receptors of the foot with chlorothane paw irrigation or 2 % lidocaine administrated into the hind paw was performed. After blocking of skin receptors of the foot the stepping pattern changed. Stepping with dorsal foot placement and dragging during swing phase was observed. Duration of stance phase significantly decreased. Inhibition of polysynaptic activity of proximal and distal extensor muscles and distal flexor muscles of hind paw during locomotion was found. Monosynaptic responses after blocking of skin receptors of the foot changed insignificantly.
在去大脑猫中研究了后爪皮肤传入输入在硬膜外脊髓刺激诱导的运动模式形成中的作用。通过对L4-L5脊髓节段背表面进行连续3-5Hz刺激来诱发运动活动。记录了一侧后肢皮肤感受器阻断前后股四头肌、半腱肌、胫骨前肌和外侧腓肠肌的运动学和肌电图活动（EMG）。此外，还分析了后肢肌肉对0.5Hz硬膜外刺激的反射反应。通过用氯乙烷爪冲洗或在后爪注射2%利多卡因来阻断足部皮肤感受器。足部皮肤感受器阻断后，步行动态发生改变。观察到在摆动期足背着地并拖地的步态。站立期持续时间显著缩短。发现运动过程中后爪近端和远端伸肌以及远端屈肌的多突触活动受到抑制。足部皮肤感受器阻断后单突触反应变化不明显。
