Fedorov G S, Arokina N K
Ross Fiziol Zh Im I M Sechenova. 2007 Oct;93(10):1171-80.
In rats, data on influence of i. v. administration of calcium chloride on the level of [Ca2+] in the blood and on process of oppression ofthermoregulatory and respiratory functions in rats in hypothermia. 0.18 or 0.135 mmol Ca2+ on the 3rd minute from beginning of the administration increased [Ca2+] in the blood from 1.01 +/- 0.03 to 2.56 +/- 0.08 mM (or 2.27 +/- 0.06 mM). Then [Ca2+] was reduced gradually, in 20 minutes from administration, solution of CaCh [Ca2+] exceeded the initial level by 20-30 %. The increase of concentration of ionized calcium in the rat blood strengthened the cold oppression of breathing and cold shivering as compared with the control (administration of physiological solution). Arrest of breathing in rats after administration of CaCl2 solution occurred at higher rectal temperatures (21 +/- 0.03 degrees C) as compared with control experiments (18 +/- 0.4 degrees C), p < 0.05. It is suggested that increase of [Ca2+] in the blood strengthens effects of cold in the form of oppression of thermoregulatory and respiratory functions.
在大鼠中，关于静脉注射氯化钙对血液中[Ca2+]水平以及对低温状态下大鼠体温调节和呼吸功能受抑制过程影响的数据。给药开始后第3分钟，0.18或0.135 mmol Ca2+使血液中[Ca2+]从1.01±0.03 mM增加至2.56±0.08 mM（或2.27±0.06 mM）。随后[Ca2+]逐渐降低，给药20分钟时，CaCl2溶液中的[Ca2+]超过初始水平20 - 30%。与对照组（给予生理溶液）相比，大鼠血液中离子钙浓度的增加增强了呼吸的冷抑制和寒颤。与对照实验（18±0.4℃）相比，给予CaCl2溶液后大鼠呼吸停止时的直肠温度更高（21±0.03℃），p < 0.05。提示血液中[Ca2+]的增加以体温调节和呼吸功能受抑制的形式增强了寒冷的影响。
