Kawauchi Takeshi, Hoshino Mikio
Department of Anatomy, Keio University School of Medicine, Tokyo, Japan.
Dev Neurosci. 2008;30(1-3):36-46. doi: 10.1159/000109850.
Neuronal migration is a pivotal step for architectural and functional brain development. Migrating neurons exhibit various morphological changes, based on cytoskeletal organization. In addition to many genetic studies revealing the involvement of several cytoskeletal and signaling molecules in cortical neuronal migration (e.g. doublecortin, Lis1, Filamin A, cyclin-dependent kinase 5, Reelin and Dab1), cell biological studies and recently developed techniques, including in utero electroporation, have uncovered detailed functions of these molecules as well as novel molecules, such as Rho family GTPases, focal adhesion kinase, c-jun N-terminal kinase and p27(kip1). In this review, we introduce the molecular pathways underlying cortical neuronal migration and morphological changes, with particular focus on recent findings for the regulatory mechanisms of actin cytoskeleton and microtubules.
神经元迁移是大脑结构和功能发育的关键步骤。迁移的神经元基于细胞骨架组织呈现出各种形态变化。除了许多遗传学研究揭示了几种细胞骨架和信号分子参与皮质神经元迁移（例如双皮质素、Lis1、细丝蛋白A、细胞周期蛋白依赖性激酶5、Reelin和Dab1）之外，细胞生物学研究以及最近开发的技术，包括子宫内电穿孔，已经揭示了这些分子以及新分子（如Rho家族GTP酶、粘着斑激酶、c-jun氨基末端激酶和p27（kip1））的详细功能。在这篇综述中，我们介绍了皮质神经元迁移和形态变化的分子途径，特别关注肌动蛋白细胞骨架和微管调节机制的最新发现。
