Laub Michael T, Shapiro Lucy, McAdams Harley H
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Annu Rev Genet. 2007;41:429-41. doi: 10.1146/annurev.genet.41.110306.130346.
The dynamic range of a bacterial species' natural environment is reflected in the complexity of its systems that control cell cycle progression and its range of adaptive responses. We discuss the genetic network and integrated three-dimensional sensor/response systems that regulate the cell cycle and asymmetric cell division in the bacterium Caulobacter crescentus. The cell cycle control circuitry is tied closely to chromosome replication and morphogenesis by multiple feedback pathways from the modular functions that implement the cell cycle. The sophistication of the genetic regulatory circuits and the elegant integration of temporally controlled transcription and protein synthesis with spatially dynamic phosphosignaling and proteolysis pathways, and epigenetic regulatory mechanisms, form a remarkably robust living system.
细菌物种自然环境的动态范围反映在其控制细胞周期进程的系统复杂性及其适应性反应的范围上。我们讨论了调控新月柄杆菌细胞周期和不对称细胞分裂的遗传网络以及整合的三维传感器/反应系统。细胞周期控制电路通过来自执行细胞周期的模块化功能的多个反馈途径，与染色体复制和形态发生紧密相连。遗传调控电路的复杂性，以及时间控制的转录和蛋白质合成与空间动态磷酸信号传导和蛋白水解途径以及表观遗传调控机制的巧妙整合，形成了一个非常稳健的生命系统。
