Kanoh Junko, Yanagida Mitsuhiro
Graduate School of Biostudies, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Genes Cells. 2007 Dec;12(12):1301-4. doi: 10.1111/j.1365-2443.2007.01142.x.
A recent paper (Hayashi et al. 2007) in this issue of Genes to Cells shows that the fission yeast Schizosaccharomyces pombe Tel2, a homologue of mammalian/worm CLK2/Clk-2/Rad-5, physically interacts with all the phosphoinositide 3-kinase-related kinases (PIKKs) that include Rad3/Tel1 (ATR/ATM homologues), Tor1/Tor2 (TOR kinases) and Tra1/Tra2 (TRRAP homologues), raising the possibility that Tel2 family proteins link various PIKK-related cellular processes by interacting with PIKK family proteins. In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed.
本期《基因与细胞》杂志上最近发表的一篇论文（林等人，2007年）表明，裂殖酵母粟酒裂殖酵母中的Tel2，作为哺乳动物/线虫CLK2/Clk-2/Rad-5的同源物，与所有磷酸肌醇3激酶相关激酶（PIKKs）发生物理相互作用，这些激酶包括Rad3/Tel1（ATR/ATM同源物）、Tor1/Tor2（TOR激酶）和Tra1/Tra2（TRRAP同源物），这增加了Tel2家族蛋白通过与PIKK家族蛋白相互作用来连接各种与PIKK相关的细胞过程的可能性。在这篇小型综述中，将讨论这些发现的意义和影响，以及PIKKs通过Tel2在功能上相关的可能性。
