Cagatay A Atahan, Taranoglu Ozer, Alpay Nilufer, Tufan Fatih, Karadeniz Asli, Kapmaz Mahir, Buyukbabani Nesimi
Mycoses. 2008 Jan;51(1):81-2. doi: 10.1111/j.1439-0507.2007.01419.x.
A 37-year-old female patient was diagnosed with ulcerative colitis 8 months ago and medical treatment with oral azathioprine, low-dose corticosteroids and 5-ASA was started. Following 3 months without any symptoms, the patient had total colectomy and ileostomy. After this period, liposomal amphotericin B (3 mg kg(-1) day(-1)) was given with the diagnosis of probable fungal infection. Palpable purpuric skin lesions on the anterior surface of both legs appeared on the 55th day of amphotericin B treatment. Histological examination of a skin biopsy was consistent with leucocytoclastic vasculitis. We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.
一名37岁女性患者8个月前被诊断为溃疡性结肠炎，开始口服硫唑嘌呤、低剂量皮质类固醇和5-氨基水杨酸进行药物治疗。在无症状3个月后，患者接受了全结肠切除术和回肠造口术。在此之后，鉴于可能存在真菌感染，给予了脂质体两性霉素B（3 mg kg⁻¹ 天⁻¹）治疗。在两性霉素B治疗的第55天，双腿前侧出现了可触及的紫癜性皮肤病变。皮肤活检的组织学检查结果与白细胞破碎性血管炎相符。我们报告了一例皮肤白细胞破碎性血管炎病例，推测两性霉素B可能是病因。
