用骨闪烁扫描术检测银屑病亚临床关节受累情况及其对口服甲氨蝶呤的反应。
Detection of subclinical joint involvement in psoriasis with bone scintigraphy and its response to oral methotrexate.
作者信息
Raza N, Hameed A, Ali M K
机构信息
Department of Dermatology, Combined Military Hospital, Abbottabad, Pakistan.
出版信息
Clin Exp Dermatol. 2008 Jan;33(1):70-3. doi: 10.1111/j.1365-2230.2007.02581.x. Epub 2007 Dec 10.
Subclinical joint involvement in psoriasis has been found with bone scintigraphy. In this study, 35 of 50 (70%) patients with psoriasis without clinical arthropathy had joint involvement on bone scintigraphy. Patients with positive bone scans were started on oral methotrexate, and 20 patients who completed treatment had repeat bone scintigraphy. Of the 20 patients, the post-treatment bone scans found that 12 (60%) had involvement of different sets of joints, 1 (5%) had no change and 7 (35%) patients had fewer joints involved. We suggest that subclinical joint involvement in psoriasis can be detected with bone scintigraphy, and that it is fleeting in nature. A certain degree of treatment-induced regression of joint involvement on bone scintigraphy may be possible.
通过骨闪烁显像已发现银屑病存在亚临床关节受累情况。在本研究中，50例无临床关节病的银屑病患者中有35例（70%）在骨闪烁显像时存在关节受累。骨扫描阳性的患者开始口服甲氨蝶呤治疗，20例完成治疗的患者进行了重复骨闪烁显像。在这20例患者中，治疗后的骨扫描发现，12例（60%）有不同关节组的受累，1例（5%）无变化，7例（35%）患者受累关节减少。我们认为，银屑病的亚临床关节受累可用骨闪烁显像检测到，且其本质是短暂的。骨闪烁显像上关节受累情况在一定程度上可能会因治疗而消退。
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