Kimak Agnieszka, Robak Ewa, Makowska Joanna, Woźniacka Anna
Department of Dermatology and Venereology, Medical University of Lodz, Hallera 1, 90-647 Lodz, Poland.
Department of Rheumatology, Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Poland.
J Clin Med. 2023 Jun 5;12(11):3850. doi: 10.3390/jcm12113850.
Psoriatic arthritis is a heterogenous chronic inflammatory disease that develops over time in some patients with psoriasis. The course of the disease is variable, with a broad clinical spectrum. The management of PsA has changed tremendously over the last decade, thanks to earlier diagnosis, a multidisciplinary approach and progress in pharmacological therapies. Therefore, screening for risk factors and the early signs of arthritis is highly important and recommended. Currently, research is focused on finding soluble biomarkers and developing imaging techniques that can improve the prediction of psoriatic arthritis. Among imaging modalities, ultrasonography seems to be the most accurate in detecting subclinical inflammation. Early intervention is based on the assumption that it is possible to prevent or delay psoriatic arthritis if systemic treatment for psoriasis can be administered early enough. This review article provides an overview of the current perspectives and evidence regarding the diagnosis, management and prevention of psoriatic arthritis.
银屑病关节炎是一种异质性慢性炎症性疾病，在一些银屑病患者中会随时间发展。该病病程多变，临床谱广泛。在过去十年中，由于早期诊断、多学科方法以及药物治疗的进展，银屑病关节炎的管理发生了巨大变化。因此，筛查危险因素和关节炎的早期迹象非常重要且被推荐。目前，研究集中在寻找可溶性生物标志物以及开发能够改善银屑病关节炎预测的成像技术。在各种成像方式中，超声检查在检测亚临床炎症方面似乎最为准确。早期干预基于这样一种假设，即如果能足够早地对银屑病进行全身治疗，就有可能预防或延缓银屑病关节炎。这篇综述文章概述了目前关于银屑病关节炎诊断、管理和预防的观点及证据。
