糖尿病啮齿动物的牙釉质矿物质浓度。
Enamel mineral concentration in diabetic rodents.
作者信息
Atar M, Davis G R, Verry P, Wong F S L
机构信息
Dept. Oral Growth and Developement, Section of Paediatric Dentistry, Barts and The London, Queen Mary University of London, School of Medicine and Dentistry, London, England.
出版信息
Eur Arch Paediatr Dent. 2007 Dec;8(4):195-200. doi: 10.1007/BF03262596.
AIM
This was to use x-ray microtomography (XMT), to assess the mineral composition and 3-D structure of enamel and bone in the teeth and skulls of diabetic rodents.
METHODS
Three-dimensional images of the skull were reconstructed using computer generated false colour to highlight different levels of mineralization in bone and enamel.
RESULTS
These showed that diabetic rodents exhibited more wear in their teeth. Deformities were observed in the alveolar process of the mandible and maxilla. Regions of extensive hypomineralization were found in the calvarial bone of skulls. The maximum mineral concentrations and the time constants for diabetic rodents were similar to the controls. The diabetic mice appeared to have random regions of hypomineralization and one diabetic rat had areas of hypoplasia in the mandibular incisors.
CONCLUSIONS
Diabetes may have a detrimental influence on the function of ameloblasts in laying down enamel.
目的
运用X射线显微断层扫描技术（XMT）评估糖尿病啮齿动物牙齿和颅骨中牙釉质及骨骼的矿物质组成和三维结构。
方法
利用计算机生成的伪彩色重建颅骨的三维图像，以突出骨骼和牙釉质中不同程度的矿化情况。
结果
这些结果表明，糖尿病啮齿动物的牙齿磨损更严重。在下颌骨和上颌骨的牙槽突中观察到畸形。在颅骨的颅盖骨中发现了广泛的矿化不足区域。糖尿病啮齿动物的最大矿物质浓度和时间常数与对照组相似。糖尿病小鼠似乎有随机分布的矿化不足区域，一只糖尿病大鼠的下颌切牙有发育不全区域。
结论
糖尿病可能对成釉细胞形成牙釉质的功能产生有害影响。
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