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The Synergistic Local Immunosuppressive Effects of Neural Stem Cells Expressing Indoleamine 2,3-Dioxygenase (IDO) in an Experimental Autoimmune Encephalomyelitis (EAE) Animal Model.在实验性自身免疫性脑脊髓炎（EAE）动物模型中，表达吲哚胺2,3-双加氧酶（IDO）的神经干细胞的协同局部免疫抑制作用。
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本文引用的文献

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Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis.间充质干细胞可有效调节实验性自身免疫性脑脊髓炎中的致病性免疫反应。
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A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells.孕期多发性硬化症缓解的一种潜在机制：树突状细胞介导雌激素诱导吲哚胺2,3-双加氧酶。
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Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression.神经前体细胞通过外周免疫抑制减轻自身免疫性脑脊髓炎。
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The immunoregulatory role of IDO-producing human dendritic cells revisited.重新审视产生吲哚胺2,3-双加氧酶的人树突状细胞的免疫调节作用。
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Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite.用一种合成色氨酸代谢物治疗自身免疫性神经炎症。
Science. 2005 Nov 4;310(5749):850-5. doi: 10.1126/science.1117634.
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Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.神经球衍生的多能前体细胞通过免疫调节机制促进神经保护。
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Stem cell and progenitor cell transplantation in multiple sclerosis: the discrepancy between neurobiological attraction and clinical feasibility.干细胞和祖细胞移植治疗多发性硬化症：神经生物学吸引力与临床可行性之间的差异。
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10
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.间充质干细胞通过诱导T细胞无能来改善实验性自身免疫性脑脊髓炎。
Blood. 2005 Sep 1;106(5):1755-61. doi: 10.1182/blood-2005-04-1496. Epub 2005 May 19.

干细胞通过吲哚胺2,3-双加氧酶（IDO）机制改善实验性自身免疫性脑脊髓炎（EAE）。

Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism.

作者信息

Matysiak Mariola, Stasiołek Mariusz, Orłowski Wojciech, Jurewicz Anna, Janczar Szymon, Raine Cedric S, Selmaj Krzysztof

机构信息

Department of Neurology, Medical University of Lodz, Lodz, Poland.

出版信息

J Neuroimmunol. 2008 Jan;193(1-2):12-23. doi: 10.1016/j.jneuroim.2007.07.025.

DOI:10.1016/j.jneuroim.2007.07.025
PMID:18077006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2681256/
Abstract

Syngeneic, pluripotent Lin(-)Sca1(+) bone marrow stem cells (SC), transferred to mice with experimental autoimmune encephalomyelitis, a model of multiple sclerosis, enhanced recovery, prevented relapses and promoted myelin repair. SC-treated mice showed elevated interferon-gamma production and induction of indoleamine 2,3-dioxygenase (IDO) in CD11c(+) dendritic cells (DC). IDO induction was specific since in the presence of IDO-producing CD11c(+) DC, PLP stimulated T cell proliferation was inhibited and the IDO-inhibitor, 1-MT, abrogated the SC effect. Relapse prevention during chronic disease correlated with decreased responsiveness to PLP(178-191) and MBP(85-99). Thus, pluripotent SC induce IDO in DC leading to inhibition of antigen reactivity and spreading in EAE.

摘要

同基因多能性Lin(-)Sca1(+)骨髓干细胞（SC）被移植到患有实验性自身免疫性脑脊髓炎（一种多发性硬化症模型）的小鼠体内后，可促进恢复、预防复发并促进髓鞘修复。经SC治疗的小鼠在CD11c(+)树突状细胞（DC）中表现出干扰素-γ产生增加以及吲哚胺2,3-双加氧酶（IDO）的诱导。IDO诱导具有特异性，因为在存在产生IDO的CD11c(+)DC的情况下，PLP刺激的T细胞增殖受到抑制，并且IDO抑制剂1-MT消除了SC的作用。慢性疾病期间的复发预防与对PLP(178-191)和MBP(85-99)的反应性降低相关。因此，多能性SC在DC中诱导IDO，导致在实验性自身免疫性脑脊髓炎中抗原反应性和扩散受到抑制。