胎儿暴露于异维甲酸——一个国际性问题。

Fetal exposure to isotretinoin-an international problem.

作者信息

Garcia-Bournissen Facundo, Tsur Lilach, Goldstein Lee H, Staroselsky Arthur, Avner Marina, Asrar Farhan, Berkovitch Matitiahu, Straface Gianluca, Koren Gideon, De Santis Marco

机构信息

Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Canada.

出版信息

Reprod Toxicol. 2008 Jan;25(1):124-8. doi: 10.1016/j.reprotox.2007.10.005. Epub 2007 Oct 25.

DOI:10.1016/j.reprotox.2007.10.005

PMID:18077132

Abstract

BACKGROUND

Isotretinoin is a known teratogen. Pregnancy prevention programs aimed at minimizing isotretinoin exposure in pregnancy have been implemented in North America with limited success.

OBJECTIVE

To compare the management of fetal risk of isotretinoin in three countries, including information given to women, implementation of contraceptive methods, and pregnancy outcomes.

METHODS

Pregnant women exposed to isotretinoin who called teratogen information services (TIS) in Israel, Italy and Canada between July 1998 and October 2006 were interviewed at the time of initial consultation and after the expected day of delivery.

RESULTS

Fifty-three pregnant women exposed to isotretinoin contacted the TIS. Only 41% reported using a birth control method. Just one patient reported using two different forms. Forty-five percent of exposed pregnancies were terminated before delivery and 22% delivered healthy babies. Two babies were born with malformations.

CONCLUSIONS

Since isotretinoin-exposed pregnancies still occur, there is a need for more effective strategies, which should take into account the cultural differences.

摘要