局部癌症对神经肌肉系统的远程影响。

Remote effects of focal cancer on the neuromuscular system.

作者信息

Engel W K, Askanas V

出版信息

Adv Neurol. 1976;15:119-47.

Abstract

The remote effects of cancer on the neuromuscular system include type II muscle fiber atrophy, dermatomyositis/polymyositis, myasthenia gravis, the facilitating myasthenic syndrome, peripheral neuropathy (including amyloid neuropathy), and possibly amyotrophic lateral sclerosis. The clinical and pathological findings and a number of possible pathokinetic mechanisms of these disorders are discussed. In none is the pathokinetic mechanism known. Hence, much work remains in therapeutically oriented research of the mechanisms in all of the remote effects of cancer on the neuromuscular system.

摘要

癌症对神经肌肉系统的远隔效应包括II型肌纤维萎缩、皮肌炎/多肌炎、重症肌无力、类重症肌无力综合征、周围神经病（包括淀粉样变性神经病），以及可能的肌萎缩侧索硬化。本文讨论了这些疾病的临床和病理表现以及一些可能的发病机制。目前尚不清楚任何一种疾病的发病机制。因此，针对癌症对神经肌肉系统所有远隔效应机制的治疗性研究仍有许多工作要做。