A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.
作者信息
Sanchez David Jesse, Miranda Daniel, Arumugaswami Vaithilingaraja, Hwang Seungmin, Singer Adam E, Senaati Ashkon, Shahangian Arash, Song Moon Jung, Sun Ren, Cheng Genhong
机构信息
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
J Virol. 2008 Mar;82(5):2208-17. doi: 10.1128/JVI.01718-07. Epub 2007 Dec 12.
Abstract
Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.
摘要
相似文献
1
A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.
J Virol. 2008 Mar;82(5):2208-17. doi: 10.1128/JVI.01718-07. Epub 2007 Dec 12.
2
Complete sequence and genomic analysis of murine gammaherpesvirus 68.
J Virol. 1997 Aug;71(8):5894-904. doi: 10.1128/JVI.71.8.5894-5904.1997.
3
Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection.
J Virol. 2014 Feb;88(4):2268-78. doi: 10.1128/JVI.03278-13. Epub 2013 Dec 11.
4
A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins.
J Virol. 1997 Mar;71(3):1963-74. doi: 10.1128/JVI.71.3.1963-1974.1997.
5
A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality.
PLoS Pathog. 2011 Nov;7(11):e1002371. doi: 10.1371/journal.ppat.1002371. Epub 2011 Nov 17.
6
The Antagonism between the Murine Gammaherpesvirus Protein Kinase and Global Interferon Regulatory Factor 1 Expression Shapes the Establishment of Chronic Infection.
J Virol. 2022 Oct 26;96(20):e0126022. doi: 10.1128/jvi.01260-22. Epub 2022 Sep 28.
7
Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins.
J Gen Virol. 2010 Sep;91(Pt 9):2203-15. doi: 10.1099/vir.0.020958-0. Epub 2010 May 19.
8
Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus.
J Virol. 2019 Nov 26;93(24). doi: 10.1128/JVI.01422-19. Print 2019 Dec 15.
9
Chromatin organization of gammaherpesvirus latent genomes.
Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):236-45. doi: 10.1016/j.bbagrm.2009.10.004. Epub 2009 Oct 22.
10
A Gammaherpesvirus MicroRNA Targets EWSR1 (Ewing Sarcoma Breakpoint Region 1) To Promote Latent Infection of Germinal Center B Cells.
mBio. 2019 Jul 30;10(4):e00996-19. doi: 10.1128/mBio.00996-19.
引用本文的文献
1
The Roles of Type I Interferon in Bacterial Infection.
Cell Host Microbe. 2016 Jun 8;19(6):760-9. doi: 10.1016/j.chom.2016.05.016.
2
Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4306-15. doi: 10.1073/pnas.1503831112. Epub 2015 Jul 21.
3
Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system.
Cytokine Growth Factor Rev. 2014 Oct;25(5):597-609. doi: 10.1016/j.cytogfr.2014.06.001. Epub 2014 Jun 21.
4
Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages.
Virology. 2013 Aug 15;443(1):123-33. doi: 10.1016/j.virol.2013.04.036. Epub 2013 May 23.
5
Suppression of TLR9 immunostimulatory motifs in the genome of a gammaherpesvirus.
J Immunol. 2011 Jul 15;187(2):887-96. doi: 10.4049/jimmunol.1003737. Epub 2011 Jun 10.
6
Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF).
J Biol Chem. 2011 Mar 11;286(10):7865-7872. doi: 10.1074/jbc.M110.191452. Epub 2011 Jan 6.
7
Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B.
J Virol. 2010 Sep;84(17):8913-25. doi: 10.1128/JVI.00169-10. Epub 2010 Jun 23.
8
Kaposi's sarcoma-associated herpesvirus and innate immunity.
Future Virol. 2010 Mar 1;5(2):185-196. doi: 10.2217/fvl.10.5.
9
Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.
J Virol. 2010 Jan;84(1):585-98. doi: 10.1128/JVI.01748-09.
10
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Nat Immunol. 2009 Oct;10(10):1065-72. doi: 10.1038/ni.1779. Epub 2009 Jul 16.
本文引用的文献
1
Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267.
J Immunol. 2015 Sep 1;195(5):1911-20.
2
Immune evasion by Kaposi's sarcoma-associated herpesvirus.
Nat Rev Immunol. 2007 May;7(5):391-401. doi: 10.1038/nri2076.
3
5'-Triphosphate RNA is the ligand for RIG-I.
Science. 2006 Nov 10;314(5801):994-7. doi: 10.1126/science.1132505. Epub 2006 Oct 12.
4
Complex modulation of cell type-specific signaling in response to type I interferons.
Immunity. 2006 Sep;25(3):361-72. doi: 10.1016/j.immuni.2006.08.014.
5
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.
Immunity. 2006 Sep;25(3):349-60. doi: 10.1016/j.immuni.2006.08.009.
6
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature. 2006 May 4;441(7089):101-5. doi: 10.1038/nature04734. Epub 2006 Apr 9.
7
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
Immunity. 2006 Jan;24(1):93-103. doi: 10.1016/j.immuni.2005.12.003.
8
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.
Nat Immunol. 2006 Jan;7(1):49-56. doi: 10.1038/ni1280. Epub 2005 Dec 11.
9
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation.
J Exp Med. 2005 Nov 21;202(10):1333-9. doi: 10.1084/jem.20051654.
10
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Nat Immunol. 2006 Jan;7(1):40-8. doi: 10.1038/ni1282. Epub 2005 Nov 13.
Zotero 插件