Hou Lin, Yao Bing
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2007 Nov;13(11):1028-31.
Spermatogonial stem cells are a population of immortal cells, capable of self-renewal and multi-directional differentiation. The theory of the "stem cell niche" was originally proposed for the hematopoietic system, and niches also exist in testicular tissues. The niche for spermatogonial stem cells is a semi-isolation system, characteristic of specific number regulation and changing with the age. The self-renewal of spermatogonial stem cells is regulated by two endogenous factors, nanos2 and Plzf, as well as by the niche cell-excreted factor, glial-derived neurotrophic factor (GDNF).
精原干细胞是一群永生细胞，具有自我更新和多向分化能力。“干细胞微环境”理论最初是针对造血系统提出的，睾丸组织中也存在微环境。精原干细胞的微环境是一个半隔离系统，具有特定数量调节的特征，并随年龄变化。精原干细胞的自我更新受两种内源性因子nanos2和Plzf以及微环境细胞分泌因子胶质细胞源性神经营养因子（GDNF）的调节。
