Schlesinger L, Ohlbaum A, Grez L, Stekel A
Am J Clin Nutr. 1976 Jul;29(7):758-61. doi: 10.1093/ajcn/29.7.758.
Interferon production by leukocytes in culture was investigated in nine severely marasmic infants and 31 well-nourished controls. The production of interferon was induced with Newcastle disease virus and assayed in Vero cells challenged with vesicular stomatitis virus. Marasmic infants produced significantly less interferon than controls. It is suggested that the finding may be the result of a lymphocyte defect induced by malnutrition and could help to explain the increased frequency and severity of viral diseases in this condition.
对9名重度消瘦婴儿和31名营养良好的对照者进行了研究，以观察培养的白细胞产生干扰素的情况。用新城疫病毒诱导干扰素的产生，并在受到水泡性口炎病毒攻击的非洲绿猴肾细胞中进行检测。消瘦婴儿产生的干扰素明显少于对照者。这一发现可能是营养不良引起的淋巴细胞缺陷所致，有助于解释在这种情况下病毒性疾病发病率和严重程度增加的原因。
