β淀粉样肽与微管相关蛋白1B（MAP1B）结合。
Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).
作者信息
Gevorkian Goar, Gonzalez-Noriega Alfonso, Acero Gonzalo, Ordoñez Jorge, Michalak Colette, Munguia Maria Elena, Govezensky Tzipe, Cribbs David H, Manoutcharian Karen
机构信息
Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Apartado Postal 70228, Cuidad Universitaria, Mexico DF, CP 04510, Mexico.
出版信息
Neurochem Int. 2008 May;52(6):1030-6. doi: 10.1016/j.neuint.2007.10.020. Epub 2007 Nov 12.
Abstract
Extracellular and intraneuronal formation of amyloid-beta aggregates have been demonstrated to be involved in the pathogenesis of Alzheimer's disease. However, the precise mechanism of amyloid-beta neurotoxicity is not completely understood. Previous studies suggest that binding of amyloid-beta to a number of targets have deleterious effects on cellular functions. In the present study we have shown for the first time that amyloid-beta 1-42 bound to a peptide comprising the microtubule binding domain of the heavy chain of microtubule-associated protein 1B by the screening of a human brain cDNA library expressed on M13 phage. This interaction may explain, in part, the loss of neuronal cytoskeletal integrity, impairment of microtubule-dependent transport and synaptic dysfunction observed previously in Alzheimer's disease.
摘要
淀粉样β蛋白聚集体在细胞外和神经元内的形成已被证明与阿尔茨海默病的发病机制有关。然而，淀粉样β蛋白神经毒性的确切机制尚未完全明确。先前的研究表明，淀粉样β蛋白与许多靶点的结合对细胞功能具有有害影响。在本研究中，我们首次通过筛选在M13噬菌体上表达的人脑cDNA文库，发现淀粉样β1-42与包含微管相关蛋白1B重链微管结合结构域的肽段相结合。这种相互作用可能部分解释了先前在阿尔茨海默病中观察到的神经元细胞骨架完整性丧失、微管依赖性运输受损和突触功能障碍。
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本文引用的文献
1
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Nat Rev Neurosci. 2007 Jul;8(7):499-509. doi: 10.1038/nrn2168.
2
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Eur J Pharmacol. 2007 May 7;562(1-2):20-7. doi: 10.1016/j.ejphar.2007.01.053. Epub 2007 Feb 8.
3
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Brain Res Bull. 2007 Mar 30;71(6):610-8. doi: 10.1016/j.brainresbull.2006.12.003. Epub 2007 Jan 3.
4
Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein.微管相关蛋白1B，一种与生长相关的磷酸化支架蛋白。
Brain Res Bull. 2007 Mar 30;71(6):541-58. doi: 10.1016/j.brainresbull.2006.11.012. Epub 2006 Dec 27.
5
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Neurochem Int. 2007 Jan;50(1):74-82. doi: 10.1016/j.neuint.2006.07.016. Epub 2006 Sep 12.
6
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Nat Med. 2006 Jul;12(7):764-5; discussion 765. doi: 10.1038/nm0706-764.
7
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9
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10
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