既往流产与低出生体重及早产风险
Previous abortion and the risk of low birth weight and preterm births.
作者信息
Brown J S, Adera T, Masho S W
机构信息
Virginia Commonwealth University, Department of Epidemiology and Community Health, Richmond, VA 23298-0212, USA.
出版信息
J Epidemiol Community Health. 2008 Jan;62(1):16-22. doi: 10.1136/jech.2006.050369.
OBJECTIVE
To investigate the association between previous abortion and low birth weight (LBW) and preterm birth (PB).
METHOD
The study examined live, singleton births using data from the United States Collaborative Perinatal Project. Logistic regression was used to control for obstetric and medical history, and lifestyle and demographic factors.
RESULT
Compared with women with no history of abortion, women who had one, two and three or more previous abortions were 2.8 (95% CI 2.48 to 3.07), 4.6 (95% CI 3.94 to 5.46) and 9.5 (95% CI 7.72 to 11.67) times more likely to have LBW, respectively. The risk for PB was also 1.7 (95% CI 1.52 to 1.83), 2.0 (95% CI 1.73 to 2.37) and 3.0 (95% CI 2.47 to 3.70) times higher for women with a history of one, two and three or more previous abortions, respectively.
CONCLUSION
Previous abortion is a significant risk factor for LBW and PB, and the risk increases with the increasing number of previous abortions. Practitioners should consider previous abortion as a risk factor for LBW and PB.
目的
探讨既往流产与低出生体重（LBW）及早产（PB）之间的关联。
方法
本研究使用来自美国围产期协作项目的数据，对活产单胎分娩进行了调查。采用逻辑回归分析来控制产科和病史、生活方式及人口统计学因素。
结果
与无流产史的女性相比，既往有1次、2次以及3次或更多次流产史的女性发生低出生体重的可能性分别高出2.8倍（95%可信区间为2.48至3.07）、4.6倍（95%可信区间为3.94至5.46）和9.5倍（95%可信区间为7.72至11.67）。既往有1次、2次以及3次或更多次流产史的女性早产风险也分别高出1.7倍（95%可信区间为1.52至1.83）、2.0倍（95%可信区间为1.73至2.37）和3.0倍（95%可信区间为2.47至3.70）。
结论
既往流产是低出生体重和早产的重要危险因素，且风险随着既往流产次数的增加而升高。从业者应将既往流产视为低出生体重和早产的危险因素。
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