Osler M, Nybo Andersen A-M, Nordentoft M
Epidemiology Unit, Institute of Public Health, University of Southern Denmark, 5000, Odense C, Denmark.
J Epidemiol Community Health. 2008 Jan;62(1):23-8. doi: 10.1136/jech.2006.053330.
Few studies have examined the correlation between social circumstances during childhood and adult suicide behaviour in a prospective design. How indicators of impaired childhood development affect the risk of suicide behaviour before the age of 50 years are analysed in this study.
9359 Men born in Copenhagen, Denmark, in 1953, who had completed conscription medical examination at approximately 18 years of age and for whom birth certificates had been traced were followed from 1972 to 2003 in Danish health registers regarding suicide or suicide attempts. At the age of 12 years 6856 of these cohort members had completed a cognitive performance test.
During follow-up, 92 (1.0%) and 228 (2.4%) of the men, respectively, committed suicide or had one or more suicide attempt. Low body mass index (BMI), low cognitive test score, and mental disorder at the age of 18 years were associated with an increased risk of suicide. After adjustment, mental disorder remained significantly associated with suicide risk (hazard ratio 2.49, 95% CI 1.03 to 6.02), whereas the estimates for cognitive function (HR 0.77, 95% CI 0.59 to 1.01) and BMI (HR 0.81, 95% CI 0.64 to 1.02) were attenuated. In the crude analyses suicide attempt was associated with all indicators, but after adjustment mental disorder (HR 2.64 (95% CI 1.55 to 4.49), no more than a basic school education (HR 2.28, 95% CI 1. 30 to 4.00), BMI (HR 0.87, 95% CI 0.75 to 1.00) and cognitive test score at the age of 18 years (HR 0.85, 95% CI 0.72 to 1.01) were associated with the risk of suicide attempt.
This study suggests that low BMI, low cognitive function, and mental disorder in early adulthood are markers of an increased risk of suicide among men born in Denmark in 1953.
很少有研究以前瞻性设计来探究儿童时期的社会环境与成人自杀行为之间的相关性。本研究分析了儿童发育受损指标如何影响50岁之前自杀行为的风险。
对1953年出生在丹麦哥本哈根的9359名男性进行研究，这些男性在18岁左右完成了征兵体检，并且找到了他们的出生证明，从1972年到2003年在丹麦健康登记处追踪他们的自杀或自杀未遂情况。在12岁时，这些队列成员中有6856人完成了认知能力测试。
在随访期间，分别有92名（1.0%）和228名（2.4%）男性自杀或有一次或多次自杀未遂。低体重指数（BMI）、低认知测试分数和18岁时的精神障碍与自杀风险增加有关。调整后，精神障碍仍然与自杀风险显著相关（风险比2.49，95%可信区间1.03至6.02），而认知功能（风险比0.77，95%可信区间0.59至1.01）和BMI（风险比0.81，95%可信区间0.64至1.02）的估计值减弱。在粗分析中，自杀未遂与所有指标相关，但调整后，精神障碍（风险比2.64（95%可信区间1.55至4.49））、不超过小学教育水平（风险比2.28，95%可信区间1.30至4.00）、BMI（风险比0.87，95%可信区间0.75至1.00）和18岁时的认知测试分数（风险比0.85，95%可信区间0.72至1.01）与自杀未遂风险相关。
本研究表明，低BMI、低认知功能和成年早期的精神障碍是1953年出生在丹麦的男性自杀风险增加的标志。
