Zarbock Alexander, Ley Klaus
Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA.
Am J Pathol. 2008 Jan;172(1):1-7. doi: 10.2353/ajpath.2008.070502. Epub 2007 Dec 13.
Leukocyte recruitment into inflamed tissue proceeds in a cascade-like fashion. The first contact of neutrophils with the endothelium is mediated by selectins and their counterreceptors, followed by rolling of neutrophils along the endothelial wall of postcapillary venules and integrin-mediated arrest. While rolling, neutrophils collect different inflammatory signals that can activate several pathways. In addition to activation of neutrophils by ligation of G-protein-coupled receptors with chemokines and other chemoattractants, integrins and selectin ligands are also able to signal into the cell, where they initiate neutrophil extravasation, promote cytoskeletal rearrangement, and ultimately induce superoxide production and degranulation. These signaling pathways may be targeted by therapeutic interventions to inhibit specific functions of neutrophils without affecting others. This Review is focused on the signaling events during the interaction of neutrophils with the endothelium.
白细胞募集到炎症组织的过程呈级联式。中性粒细胞与内皮细胞的首次接触由选择素及其反受体介导，随后中性粒细胞沿毛细血管后微静脉的内皮壁滚动，并由整合素介导停滞。在滚动过程中，中性粒细胞收集不同的炎症信号，这些信号可激活多种途径。除了通过G蛋白偶联受体与趋化因子及其他趋化剂结合来激活中性粒细胞外，整合素和选择素配体也能够向细胞内发出信号，在细胞内它们启动中性粒细胞外渗、促进细胞骨架重排，并最终诱导超氧化物产生和脱颗粒。这些信号通路可能成为治疗干预的靶点，以抑制中性粒细胞的特定功能而不影响其他功能。本综述聚焦于中性粒细胞与内皮细胞相互作用过程中的信号事件。
