Izumi Yumiko, Ishibashi Genji, Nakanishi Yumiko, Kikunaga Shigeshi
Faculty of Sciences of Human Life, Notre Dame Seishin University, Okayama, Japan.
J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):400-9. doi: 10.3177/jnsv.53.400.
Three percent milled-rice was evaluated for beneficial effect on blood glucose level and serum lipid concentrations in an experiment with Otsuka Long-Evans Tokushima Fatty (OLETF) rats, used as model animals for spontaneously non-insulin-dependent diabetes mellitus. The same experiment was carried out using Long-Evans Tokushima Otsuka (LETO) rats, the control of the OLETF rats. The results obtained from the rats given a diet containing 3% milled-rice (3% MRD) ad libitum were compared with those from rats given polished rice. During the feeding period of 140 d, body weight of the OLETF rats receiving the 3% MRD was significantly lower than that of the rats fed on the diet containing polished rice (PRD) from the 48th to the 124th days. The body weight of the LETO rats during the both periods of 90 to 104 d and 114 to 140 d was lower than that of the rats receiving the PRD. Though food intakes of the rats receiving 3% MRD were significantly lower in the OLETF and LETO rats during the two periods of days 48 to 124 and days 1 to 140 than in the rats of the PRD group, the feed efficiency of the OLETF or LETO rats did not show significant difference between the 3% MRD and the PRD groups during the same experimental periods. The excretion rate of feces of the OLETF rats receiving the 3% MRD was significantly higher than that of the rats receiving the PRD, both on the 126th day and during the period of days 129 to 131. The fasting blood glucose levels were significantly lower in the OLETF rats receiving the 3% MRD than the rats receiving the PRD on the 84th day, the 105th day and the 127th day, and also lower in the LETO rats receiving the 3% MRD on the 84th day and the 105th day. The incremental areas under the curve of blood glucose concentrations (IAUC-Glc) for 120 min after oral administration of glucose on the 133rd day was lower in the OLETF rats receiving 3% MRD than that of the PRD. The ratio of IAUC-Glc in the 3% MRD to PRD group, after ingestion of diets for 1 h after fasting for 18 h on the 138th day, was 0.89 in the OLETF rats, and 0.74 in the LETO rats. Compared with the PRD group, the amounts of cholesterol and bile acid in the feces of the OLETF rats in the 3% MRD group were significantly higher on days 129-131, and the cholesterol excretion was significantly higher on the 84th day in the OLETF rats in the 3% MRD group. The liver weight, the level of total lipids in liver, and the concentrations of triglyceride and total cholesterol in liver and serum of the OLETF rats on the 140th day were significantly lower in the 3% MRD than those of the PRD group. These results indicate that 3% milled-rice has beneficial effects on blood glucose level and serum lipid concentrations in spontaneously non-insulin-dependent diabetic rats.
在一项实验中，以大冢长- Evans 德岛肥胖（OLETF）大鼠作为自发性非胰岛素依赖型糖尿病的模型动物，评估了 3%的糙米对血糖水平和血脂浓度的有益影响。使用 OLETF 大鼠的对照——长- Evans 德岛大冢（LETO）大鼠进行了相同的实验。将随意喂食含 3%糙米（3%MRD）日粮的大鼠所获得的结果与喂食精米的大鼠的结果进行比较。在 140 天的喂养期内，从第 48 天到第 124 天，接受 3%MRD 的 OLETF 大鼠的体重显著低于喂食含精米日粮（PRD）的大鼠。在 90 至 104 天和 114 至 140 天这两个时间段内，LETO 大鼠的体重低于接受 PRD 的大鼠。尽管在第 48 至 124 天以及第 1 至 140 天这两个时间段内，接受 3%MRD 的 OLETF 和 LETO 大鼠的食物摄入量显著低于 PRD 组大鼠，但在相同实验期间，OLETF 或 LETO 大鼠在 3%MRD 和 PRD 组之间的饲料效率没有显著差异。在第 126 天以及第 129 至 131 天期间，接受 3%MRD 的 OLETF 大鼠的粪便排泄率显著高于接受 PRD 的大鼠。在第 84 天、第 105 天和第 127 天，接受 3%MRD 的 OLETF 大鼠的空腹血糖水平显著低于接受 PRD 的大鼠，在第 84 天和第 105 天，接受 3%MRD 的 LETO 大鼠的空腹血糖水平也较低。在第 133 天口服葡萄糖后 120 分钟的血糖浓度曲线下增量面积（IAUC-Glc），接受 3%MRD 的 OLETF 大鼠低于 PRD 组。在第 138 天禁食 18 小时后进食日粮 1 小时后，OLETF 大鼠中 3%MRD 组与 PRD 组的 IAUC-Glc 比值为 0.89，LETO 大鼠中为 0.74。与 PRD 组相比，在第 129 - 131 天，3%MRD 组的 OLETF 大鼠粪便中的胆固醇和胆汁酸含量显著更高，在第 84 天，3%MRD 组的 OLETF 大鼠的胆固醇排泄显著更高。在第 140 天，3%MRD 组的 OLETF 大鼠的肝脏重量、肝脏中总脂质水平以及肝脏和血清中的甘油三酯和总胆固醇浓度显著低于 PRD 组。这些结果表明，3%的糙米对自发性非胰岛素依赖型糖尿病大鼠的血糖水平和血脂浓度有有益影响。
