Bougerol T
Service Hospitalo-Universitaire de Psychiatrie d'Adultes, Hôpital Sainte-Marguerite, Marseille.
Encephale. 1991 Dec;17 Spec No 3:377-86.
Since the discovery of the first antidepressive compounds, very few progress have been made for the efficacy of these drugs. All the antidepressants, even the more recent of them, are efficient only in 60 to 75% of the depressive disorders treated. Many studies have been conducted to define clinical or psychological predictive factors of the response to antidepressants. Emphasis was carry mostly on the clinical characteristics of the depressive disorder and the importance of "endogenous" features for the response to treatment, have been well established. Some works have also emphasized the importance of personality disorders and environmental disturbances for the issues of treatment. More recent works aim to define the characteristics of the best responders to more selective antidepressive compounds. But, it is still very difficult today to define precisely what are the clinical or psychological features which are specifically responsive to antidepressive drugs.
自从发现首批抗抑郁化合物以来，这些药物的疗效几乎没有取得什么进展。所有抗抑郁药，即使是最新的，也仅对60%至75%接受治疗的抑郁症有效。已经进行了许多研究来确定对抗抑郁药反应的临床或心理预测因素。重点大多放在抑郁症的临床特征以及“内源性”特征对治疗反应的重要性上，这一点已经得到充分证实。一些研究还强调了人格障碍和环境干扰对治疗问题的重要性。最近的研究旨在确定对更具选择性的抗抑郁化合物反应最佳者的特征。但是，如今仍然很难精确界定对抗抑郁药物有特异性反应的临床或心理特征究竟是什么。
