Microwave-Enhanced Fluorous Synthesis.
作者信息
Zhang Wei
出版信息
Chim Oggi. 2005;23(3):11-13.
Abstract
A new technology for high-speed solution-phase parallel synthesis has been developed by the combination of microwave heating and fluorous tagging strategies. This article highlights several applications of this technology in the synthesis of library scaffolds involving Pd-catalyzed cross-coupling and multicomponent reactions.
摘要
相似文献
1
Microwave-Enhanced Fluorous Synthesis.
Chim Oggi. 2005;23(3):11-13.
2
Microwave-Enhanced High-Speed Fluorous Synthesis.
Top Curr Chem. 2006 Aug 30;266:145-166. doi: 10.1007/128_045.
3
Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides.
Mol Divers. 2003;7(2-4):199-202. doi: 10.1023/b:modi.0000006825.12186.5f.
4
Fluorous-enhanced multicomponent reactions for making drug-like library scaffolds.
Comb Chem High Throughput Screen. 2007 Mar;10(3):219-29. doi: 10.2174/138620707780126697.
5
Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications.
Beilstein J Org Chem. 2011;7:1294-8. doi: 10.3762/bjoc.7.150. Epub 2011 Sep 16.
6
Use of cyclohexylisocyanide and methyl 2-isocyanoacetate as convertible isocyanides for microwave-assisted fluorous synthesis of 1,4-benzodiazepine-2,5-dione library.
J Comb Chem. 2010 Jan-Feb;12(1):206-14. doi: 10.1021/cc900157w.
7
Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.
QSAR Comb Sci. 2004;23(10):827-835. doi: 10.1901/jaba.2004.23-827.
8
Microwave-assisted fluorous synthesis of a 1,4-benzodiazepine-2,5-dione library.
J Comb Chem. 2009 Nov-Dec;11(6):1083-93. doi: 10.1021/cc900109e.
9
Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library.
J Comb Chem. 2009 May-Jun;11(3):452-9. doi: 10.1021/cc900003q.
10
Plate-to-plate fluorous solid-phase extraction for solution-phase parallel synthesis.
J Comb Chem. 2005 Nov-Dec;7(6):893-7. doi: 10.1021/cc050061z.
引用本文的文献
1
Fluorous-enhanced multicomponent reactions for making drug-like library scaffolds.
Comb Chem High Throughput Screen. 2007 Mar;10(3):219-29. doi: 10.2174/138620707780126697.
本文引用的文献
1
Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.
QSAR Comb Sci. 2004;23(10):827-835. doi: 10.1901/jaba.2004.23-827.
2
Controlled microwave heating in modern organic synthesis.
Angew Chem Int Ed Engl. 2004 Nov 26;43(46):6250-84. doi: 10.1002/anie.200400655.
3
Solution-phase parallel synthesis of an N-alkylated dihydropteridinone library from fluorous amino acids.
J Comb Chem. 2004 Nov-Dec;6(6):942-9. doi: 10.1021/cc049885r.
4
Fluorous synthesis of heterocyclic systems.
Chem Rev. 2004 May;104(5):2531-56. doi: 10.1021/cr030600r.
5
A highly efficient microwave-assisted suzuki coupling reaction of aryl perfluorooctylsulfonates with boronic acids.
Org Lett. 2004 Apr 29;6(9):1473-6. doi: 10.1021/ol0496428.
6
Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides.
Mol Divers. 2003;7(2-4):199-202. doi: 10.1023/b:modi.0000006825.12186.5f.
7
Microwave-assisted polymer-supported combinatorial synthesis.
Curr Med Chem. 2003 Nov;10(22):2403-23. doi: 10.2174/0929867033456594.
Zotero 插件