微波增强氟相合成
Microwave-Enhanced Fluorous Synthesis.
作者信息
Zhang Wei
出版信息
Chim Oggi. 2005;23(3):11-13.
Abstract
A new technology for high-speed solution-phase parallel synthesis has been developed by the combination of microwave heating and fluorous tagging strategies. This article highlights several applications of this technology in the synthesis of library scaffolds involving Pd-catalyzed cross-coupling and multicomponent reactions.
摘要
通过微波加热和氟代标记策略的结合，开发出了一种用于高速溶液相平行合成的新技术。本文重点介绍了该技术在涉及钯催化交叉偶联和多组分反应的文库支架合成中的几种应用。
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引用本文的文献
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本文引用的文献
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Microwave-assisted synthesis of a 3-aminoimidazo[1,2-a]-pyridine/pyrazine library by fluorous multicomponent reactions and subsequent cross-coupling reactions.通过氟代多组分反应及后续交叉偶联反应微波辅助合成3-氨基咪唑并[1,2-a]吡啶/吡嗪文库。
QSAR Comb Sci. 2004;23(10):827-835. doi: 10.1901/jaba.2004.23-827.
2
Controlled microwave heating in modern organic synthesis.现代有机合成中的可控微波加热。
Angew Chem Int Ed Engl. 2004 Nov 26;43(46):6250-84. doi: 10.1002/anie.200400655.
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Solution-phase parallel synthesis of an N-alkylated dihydropteridinone library from fluorous amino acids.由氟代氨基酸进行N-烷基化二氢蝶啶酮文库的溶液相平行合成。
J Comb Chem. 2004 Nov-Dec;6(6):942-9. doi: 10.1021/cc049885r.
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Chem Rev. 2004 May;104(5):2531-56. doi: 10.1021/cr030600r.
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A highly efficient microwave-assisted suzuki coupling reaction of aryl perfluorooctylsulfonates with boronic acids.芳基全氟辛基磺酸盐与硼酸的高效微波辅助铃木偶联反应。
Org Lett. 2004 Apr 29;6(9):1473-6. doi: 10.1021/ol0496428.
6
Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides.钯催化合成芳基硫醚中微波反应与氟相分离的结合
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