Stacey Glyn N, Day John G
Division of Cell Biology and Imaging, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK.
Methods Mol Biol. 2007;368:1-14. doi: 10.1007/978-1-59745-362-2_1.
The establishment and maintenance of biological resource centers (BRCs) requires careful attention to implementation of reliable preservation technologies and appropriate quality control to ensure that recovered cultures and other biological materials perform in the same way as the originally isolated culture or material. There are many types of BRC that vary both in the kinds of material they hold and in the purposes for which the materials are provided. All BRCs are expected to provide materials and information of an appropriate quality for their application and work to standards relevant to those applications. There are important industrial, biomedical, and conservation issues that can only be addressed through effective and efficient operation of BRCs in the long- term. This requires a high degree of expertise in the maintenance and management of collections of biological materials at ultra-low temperatures, or as freeze-dried material, to secure their long-term integrity and relevance for future research, development, and conservation.
生物资源中心（BRCs）的建立和维护需要谨慎关注可靠保存技术的实施以及适当的质量控制，以确保复苏后的培养物和其他生物材料的表现与最初分离的培养物或材料相同。BRCs有多种类型，其保存的材料种类以及提供材料的目的各不相同。所有BRCs都应提供质量适宜的材料和信息以满足其应用需求，并按照与这些应用相关的标准开展工作。一些重要的工业、生物医学和保护问题，只有通过BRCs长期有效且高效的运作才能得到解决。这需要在超低温或冻干状态下对生物材料进行高度专业的维护和管理，以确保其长期完整性以及对未来研究、开发和保护的相关性。
