Nencioni Lucia, Sgarbanti Rossella, De Chiara Giovanna, Garaci Enrico, Palamara Anna Teresa
G. Sanarelli Department of Public Health Sciences, La Sapienza University of Rome, Italy.
New Microbiol. 2007 Oct;30(4):367-75.
Several viruses, including influenza, induce an imbalance of intracellular redox state toward pro-oxidant conditions. Through different mechanisms these alterations contribute both to influenza virus replication and to the pathogenesis of virus-induced disease. At the same time, influenza virus activates several intracellular signaling pathways involved in important physiological functions of the cell. Interestingly, many of these pathways are finely regulated by small changes in intracellular redox state, and the virus-induced redox imbalance might also control viral replication through this mechanism. Here we review the main intracellular redox-sensitive pathways activated upon influenza infection and involved in regulating viral replication.
包括流感病毒在内的多种病毒会导致细胞内氧化还原状态失衡，趋向于促氧化状态。通过不同机制，这些改变既有助于流感病毒的复制，也参与病毒诱导疾病的发病机制。同时，流感病毒会激活细胞内多条参与细胞重要生理功能的信号通路。有趣的是，其中许多通路受到细胞内氧化还原状态微小变化的精细调控，病毒诱导的氧化还原失衡也可能通过这一机制控制病毒复制。在此，我们综述流感感染后激活的、参与调节病毒复制的主要细胞内氧化还原敏感通路。
