Yanai Joseph, Dotan Sharon, Goz Roman, Pinkas Adi, Seidler Frederic J, Slotkin Theodore A, Zimmerman Frederic
The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
J Toxicol Environ Health A. 2008;71(2):131-3. doi: 10.1080/15287390701613280.
There is increasing concern over the widespread use of perfluorinated chemicals, which accumulate in various tissues and penetrate the mammalian fetus. A chick model was established for the rapid evaluation of teratogenicity of these chemicals, an important issue because developmental defects often occur at lower exposures than those required for adult systemic toxicity. Chicken eggs were injected with varying doses of perfluorooctanoic acid prior to incubation. Observed were defects in hatching, increased incidence of splayed legs, and interference with the appropriate development of yellow plumage. All these defects are potentially related to essential molecular/biochemical and functional development of the chick. Because of the relationship between structural defects and vulnerability of the developing brain, our model points to the need to evaluate neurobehavioral teratogenicity, which may involve even lower doses.
全氟化合物的广泛使用引发了越来越多的关注，这些化合物会在各种组织中蓄积并穿透哺乳动物胎儿。建立了鸡胚模型用于快速评估这些化学物质的致畸性，这是一个重要问题，因为发育缺陷通常在低于成年系统性毒性所需的暴露剂量下就会出现。在孵化前向鸡蛋注射不同剂量的全氟辛酸。观察到孵化缺陷、叉腿发生率增加以及对黄色羽毛正常发育的干扰。所有这些缺陷都可能与鸡胚的基本分子/生化和功能发育有关。由于结构缺陷与发育中大脑的易损性之间存在关联，我们的模型表明需要评估神经行为致畸性，而这可能涉及更低的剂量。
