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严重精神疾病是血源性病毒和性传播感染的一种新的风险标志物。

Severe mental illness is a new risk marker for blood-borne viruses and sexually transmitted infections.

作者信息

Lagios Katerina, Deane Frank P

机构信息

Parramatta Sexual Health Clinical Services and Cumberland Hospital, Sydney West Area Health Service, Parramatta, New South Wales, Australia.

出版信息

Aust N Z J Public Health. 2007 Dec;31(6):562-6. doi: 10.1111/j.1753-6405.2007.00144.x.

Abstract

OBJECTIVE

To determine whether severe mental illness (SMI) constitutes a risk for the acquisition of sexually transmissible infections (STIs) and blood-borne viruses (BBVs), including human immunodeficiency virus (HIV), both locally and globally.

METHOD

Database searches revealed 51 eligible studies for the review. Studies with samples of patients with SMI were analysed and compared with population data.

RESULTS

Most studies were conducted in the United States and the majority examined levels of risk behaviours. The review revealed that many countries, including Australia, had not had any prevalence studies for STIs or any BBVs among patients with SMI. STIs, HIV and other BBVs, as well as risk behaviours, were more prevalent in patients with SMI, compared with population rates. Overall, a weighted mean of 4% of patients with SMI had HIV infection and 10-20% had hepatitis C virus (HCV).

CONCLUSIONS

Severe mental illness appears to be a risk marker for the presence of STIs, HIV and other BBVs. HIV and HCV prevalences were elevated for those with risk behaviour histories, but rates also seem elevated for patients with SMI lacking such histories when compared with the general population.

IMPLICATIONS

Programs are needed, particularly in the United States, for screening all patients with SMI for STIs and BBVs to kerb this epidemic. Such strategies could also be applicable in Australia, but there is less conclusive evidence.

摘要

目的

确定严重精神疾病(SMI)在本地和全球范围内是否构成感染性传播感染(STIs)和血源病毒(BBVs)(包括人类免疫缺陷病毒(HIV))的风险。

方法

通过数据库检索发现51项符合条件的研究用于综述。对患有SMI的患者样本的研究进行了分析,并与人群数据进行了比较。

结果

大多数研究在美国进行,且大多数研究考察了风险行为水平。综述显示,包括澳大利亚在内的许多国家尚未对SMI患者进行过任何关于性传播感染或任何血源病毒的患病率研究。与人群患病率相比,性传播感染、HIV和其他血源病毒以及风险行为在SMI患者中更为普遍。总体而言,加权平均有4%的SMI患者感染了HIV,10 - 20%的患者感染了丙型肝炎病毒(HCV)。

结论

严重精神疾病似乎是性传播感染、HIV和其他血源病毒存在的风险标志物。有风险行为史的患者中HIV和HCV的患病率有所升高,但与普通人群相比,没有此类病史的SMI患者的患病率似乎也有所升高。

启示

需要开展相关项目,特别是在美国,对所有SMI患者进行性传播感染和血源病毒筛查,以遏制这一流行趋势。此类策略在澳大利亚也可能适用,但证据尚不确凿。

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