Bauer J
Department of Epileptology, Bonn University Hospital, Germany.
Acta Neurol Scand. 2008 May;117(5):374-6. doi: 10.1111/j.1600-0404.2007.00974.x. Epub 2007 Dec 12.
We report on the manifestation of a levetiracetam (LEV)-induced encephalopathy.
A 28-year-old man suffering from idiopathic epilepsy with generalized seizures was treated with LEV (3000 mg) added to valproate (VPA) (2000 mg). Frequency of generalized tonic-clonic seizures increased from one per 6 months to two per month. Neuropsychological testing showed impaired word fluency, psychomotor speed and working memory. The interictal electroencephalogram (EEG) showed a generalized slowing to 5 per second theta rhythms with bilateral generalized high-amplitude discharges.
Following discontinuation of LEV, EEG and neuropsychological findings improved and seizure frequency decreased.
