基因对饮食失调行为的影响在很大程度上独立于体重指数。

Genetic influences on disordered eating behaviour are largely independent of body mass index.

作者信息

Slof-Op 't Landt M C T, Bartels M, van Furth E F, van Beijsterveldt C E M, Meulenbelt I, Slagboom P E, Boomsma D I

机构信息

Center for Eating Disorders Ursula, Leidschendam, Amsterdam, The Netherlands.

出版信息

Acta Psychiatr Scand. 2008 May;117(5):348-56. doi: 10.1111/j.1600-0447.2007.01132.x. Epub 2007 Dec 11.

DOI:10.1111/j.1600-0447.2007.01132.x

PMID:18081919

Abstract

OBJECTIVE

Prior studies suggest eating disorders and related characteristics are moderately to substantially heritable. We are interested in identifying the genes underlying disordered eating behaviour (DEB), and want to know how much of the genetic influence underlying DEB is attributable to genetic influences on body mass index (BMI).

METHOD

Bivariate analyses were performed, in adolescent twins and siblings, to estimate the genetic and environmental contributions for DEB, BMI, and their overlap.

RESULTS

Shared genetic risk factors explained the overlap between BMI and DEB (genetic correlation was 0.43 in women, 0.51 in men). DEB was highly heritable in women (a(2) = 0.65; a(2) independent of BMI = 0.53) and moderately heritable in men (a(2) = 0.39; a(2) independent of BMI = 0.29). BMI was highly heritable in both men (a(2) = 0.76) and women (a(2) = 0.80).

CONCLUSION

The entire correlation between DEB and BMI was explained by shared genetic risk, but the majority of genetic influences on DEB were due to genetic effects independent of BMI.

摘要

目的

先前的研究表明，饮食失调及相关特征具有中等至高度的遗传性。我们感兴趣的是确定导致饮食紊乱行为（DEB）的基因，并想了解DEB背后的遗传影响中有多少可归因于对体重指数（BMI）的遗传影响。

方法

对青少年双胞胎和兄弟姐妹进行双变量分析，以估计DEB、BMI及其重叠部分的遗传和环境贡献。

结果

共同的遗传风险因素解释了BMI与DEB之间的重叠（女性的遗传相关性为0.43，男性为0.51）。DEB在女性中具有高度遗传性（a(2)=0.65；独立于BMI的a(2)=0.53），在男性中具有中等遗传性（a(2)=0.39；独立于BMI的a(2)=0.29）。BMI在男性（a(2)=0.76）和女性（a(2)=0.80）中均具有高度遗传性。