Sarvestani Alireza S, Jabbari Esmaiel
Department of Chemical Engineering, Swearingen Engineering Center, University of South Carolina, Columbia, SC 29208, USA.
J Biomech. 2008;41(4):921-5. doi: 10.1016/j.jbiomech.2007.11.004. Epub 2007 Dec 21.
An analytical model is developed for the effect of surface gradient in ligand density on the adhesion kinetics of a curved elastic membrane with mobile receptors. The displacement and speed of spreading at the edge of adhesion zone as well as the density profile of receptors along the membrane are predicted as a function of time. According to results, in the diffusion-controlled regime, the front edge displacement of adhesion zone and the rate of membrane spreading decreased with increasing the ligand density in a certain direction. Furthermore, the displacement of the edge of the adhesion zone did not scale with the square root of time, as observed on substrates with uniform ligand density.
建立了一个分析模型，用于研究配体密度的表面梯度对具有移动受体的弯曲弹性膜粘附动力学的影响。预测了粘附区边缘的位移和扩展速度以及沿膜的受体密度分布随时间的变化。根据结果，在扩散控制 regime 中，粘附区的前沿位移和膜扩展速率随着在特定方向上配体密度的增加而降低。此外，粘附区边缘的位移并不像在配体密度均匀的底物上观察到的那样与时间的平方根成比例。
