mTPH2基因C1473G单核苷酸多态性与小鼠品系间的行为差异无关。
The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains.
作者信息
Tenner Katja, Qadri Fatimunnisa, Bert Bettina, Voigt Jörg-Peter, Bader Michael
机构信息
Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin, Germany.
出版信息
Neurosci Lett. 2008 Jan 24;431(1):21-5. doi: 10.1016/j.neulet.2007.11.012. Epub 2007 Nov 17.
Tryptophan hydroxylase 2 (TPH2) is the rate limiting enzyme of serotonin synthesis in the brain. A recently described functional (C1473G) single nucleotide polymorphism in mouse TPH2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-HT levels and behaviour between mice strains. We bred two substrains of C57BL/6 mice carrying the two isoforms and could show that both exhibit equal TPH activity, brain 5-HT content and behaviour. These data indicate that the distinct behavioural characteristics of mouse strains are not due to differences in TPH2 activity, but to other variations in the genetic background.
色氨酸羟化酶2（TPH2）是大脑中血清素合成的限速酶。最近在小鼠TPH2中描述的一种功能性（C1473G）单核苷酸多态性，在体外导致酶活性大幅降低，有人怀疑它是造成不同小鼠品系之间5-羟色胺水平和行为差异的原因。我们培育了携带这两种异构体的C57BL/6小鼠的两个亚系，结果表明两者具有相同的TPH活性、脑5-羟色胺含量和行为。这些数据表明，小鼠品系不同的行为特征并非由于TPH2活性的差异，而是由于遗传背景中的其他变异。
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