Kulikov A V, Osipova D V, Naumenko V S, Popova N K
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, ave. Lavryentyev 10, 630090 Novosibirsk, Russia.
Genes Brain Behav. 2005 Nov;4(8):482-5. doi: 10.1111/j.1601-183X.2005.00145.x.
The brain neurotransmitter serotonin is involved in the regulation of aggressive behavior. The main factor determining the brain serotonin level is the activity of the rate-limiting enzyme in the biosynthesis of the neurotransmitter--tryptophan hydroxylase isoform (TPH) 2 encoded by the Tph2 gene. Recently the C1473G single-nucleotide polymorphism in the Tph2 gene was reported. Here we study the C1473G polymorphism in 10 inbred mouse strains (C57BL/6J, AKR/J, DD/He, C3H/HeJ, YT/Y, BALB/cJLac, CC57BR/Mv and A/He) and demonstrate the association of the polymorphism with brain TPH activity and intermale aggressiveness. TPH activity in the midbrain of mice homozygous for the 1473C allele was higher than that in mice carrying 1473G alleles. A close association of the 1473C allele with increased number of attacks towards another male was found. The results support a link between the C1473G polymorphism in Tph2 gene, tryptophan hydroxylase activity and intensity of intermale aggression.
大脑神经递质5-羟色胺参与攻击行为的调节。决定大脑5-羟色胺水平的主要因素是神经递质生物合成中限速酶——由Tph2基因编码的色氨酸羟化酶同工型（TPH）2的活性。最近报道了Tph2基因中的C1473G单核苷酸多态性。在此，我们研究了10个近交系小鼠品系（C57BL/6J、AKR/J、DD/He、C3H/HeJ、YT/Y、BALB/cJLac、CC57BR/Mv和A/He）中的C1473G多态性，并证明了该多态性与大脑TPH活性和雄性间攻击性的关联。纯合1473C等位基因小鼠中脑的TPH活性高于携带1473G等位基因的小鼠。发现1473C等位基因与对另一只雄性攻击次数增加密切相关。这些结果支持了Tph2基因中的C1473G多态性、色氨酸羟化酶活性和雄性间攻击强度之间的联系。
