Hourmant Maryvonne
Service de néphrologie et d'immunologie clinique, CHU de Nantes, 44093 Nantes cedex, France.
Nephrol Ther. 2008 Feb;4(1):67-8. doi: 10.1016/j.nephro.2007.07.016. Epub 2007 Dec 20.
There is no zero risk of morbi-mortality for the donor in the procedure of living donation of a kidney but according to the literature, this risk is extremely low. Mortality in the per- et peri-operative period is estimated to be 0.03% and severe postoperative complications, requiring or not surgery, between 0.3 and 1%. The long-term mortality of these donors, selected for their good health, is better than that of the general population paired for age. Renal function after donation is around 75% the predonation and declines with age as and no more than in every person with two kidneys. Although significant proteinuria (>1gr/l) in 3% of the donors and cases of end stage renal disease have been reported, the renal risk remains low. Among the parameters of follow-up, a special consideration has to be made for blood pressure as it will significantly increase after nephrectomy with a possible risk of developing hypertension in predisposed persons.
在活体肾捐赠过程中，供体不存在零病残死亡率风险，但根据文献记载，这种风险极低。围手术期死亡率估计为0.03%，术后严重并发症（无论是否需要手术）发生率在0.3%至1%之间。这些因健康状况良好而被选中的供体的长期死亡率低于同龄普通人群。捐赠后的肾功能约为捐赠前的75%，且随年龄增长而下降，与拥有两个肾脏的正常人无异。虽然有报道称3%的供体出现大量蛋白尿（>1g/L）以及终末期肾病病例，但肾脏风险仍然较低。在随访参数中，必须特别关注血压，因为肾切除术后血压会显著升高，易感人群可能有患高血压的风险。
