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2
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本文引用的文献

1
Metabolism of a highly selective gelatinase inhibitor generates active metabolite.一种高选择性明胶酶抑制剂的代谢产生活性代谢物。
Chem Biol Drug Des. 2007 Nov;70(5):371-82. doi: 10.1111/j.1747-0285.2007.00577.x. Epub 2007 Oct 10.
2
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.基质金属蛋白酶-9（MMP-9）与五种抑制剂复合物的晶体结构：柔性精氨酸424侧链对选择性的贡献
J Mol Biol. 2007 Aug 24;371(4):989-1006. doi: 10.1016/j.jmb.2007.05.068. Epub 2007 May 31.
3
Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV.饿死疟原虫：对天冬氨酸蛋白酶疟原虫蛋白酶I、II和IV有活性的抑制剂
Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2138-41. doi: 10.1002/anie.200504119.
4
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.一种新型的基于机制的选择性明胶酶抑制剂在骨转移模型中对人前列腺癌生长、骨溶解和血管生成的抑制作用
Int J Cancer. 2006 Jun 1;118(11):2721-6. doi: 10.1002/ijc.21645.
5
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.作为选择性明胶酶抑制剂的手性2-(4-苯氧基苯基磺酰甲基)硫杂环丙烷的合成。
Org Lett. 2005 Sep 29;7(20):4463-5. doi: 10.1021/ol0517269.
6
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.基质金属蛋白酶-9的一种高度特异性抑制剂可在短暂性局灶性脑缺血中使层粘连蛋白免受蛋白水解，并使神经元免受凋亡。
J Neurosci. 2005 Jul 6;25(27):6401-8. doi: 10.1523/JNEUROSCI.1563-05.2005.
7
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.一种新型基于机制的明胶酶抑制剂的抗转移活性
Cancer Res. 2005 May 1;65(9):3523-6. doi: 10.1158/0008-5472.CAN-04-3570.
8
Extracellular proteases as targets for treatment of cancer metastases.细胞外蛋白酶作为癌症转移治疗的靶点。
Chem Soc Rev. 2004 Sep 10;33(7):401-9. doi: 10.1039/b209224g. Epub 2004 Aug 13.
9
A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent.一种作为抗转移剂的选择性明胶酶抑制剂的简便合成方法。
J Org Chem. 2004 May 14;69(10):3572-3. doi: 10.1021/jo049857v.
10
N,N-dimethyl glycine-promoted Ullmann coupling reaction of phenols and aryl halides.N,N-二甲基甘氨酸促进的酚类与芳基卤化物的乌尔曼偶联反应。
Org Lett. 2003 Oct 16;5(21):3799-802. doi: 10.1021/ol0350947.

基于硫杂环丙烷的明胶酶抑制剂的构象分析。

Conformational analyses of thiirane-based gelatinase inhibitors.

作者信息

Lee Mijoon, Hesek Dusan, Shi Qicun, Noll Bruce C, Fisher Jed F, Chang Mayland, Mobashery Shahriar

机构信息

Department of Chemistry and Biochemistry, Walther Cancer Research Center, University of Notre Dame, Notre Dame, IN 46556, USA.

出版信息

Bioorg Med Chem Lett. 2008 May 15;18(10):3064-7. doi: 10.1016/j.bmcl.2007.11.131. Epub 2007 Dec 5.

DOI:10.1016/j.bmcl.2007.11.131
PMID:18083555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3286628/
Abstract

SB-3CT is a thiirane-containing inhibitor of the gelatinase class of matrix metalloprotease enzymes. In support of the mechanistic study of this inhibition, the conformational analyses of SB-3CT (and of two methyl-substituted derivatives) were undertaken using X-ray crystallography and molecular dynamics simulation.

摘要

SB - 3CT是一种含硫杂环丙烷的基质金属蛋白酶明胶酶类抑制剂。为支持这种抑制作用的机制研究，采用X射线晶体学和分子动力学模拟对SB - 3CT（以及两种甲基取代衍生物）进行了构象分析。