Imai Kenji, Ariga Hajime, Chen Cindy, Mantyh Christopher, Pappas Theodore N, Takahashi Toku
Department of Surgery, Duke University, Durham, North Carolina, United States.
Auton Neurosci. 2008 Feb 29;138(1-2):91-8. doi: 10.1016/j.autneu.2007.11.003.
To clarify the mechanism of site-specific effects of acupuncture on gastric motor function, we studied the simultaneous recording of gastric motility and electrocardiogram (ECG) for heart rate variability (HRV) analysis in conscious rats. Gastric motility and ECG were recorded before, during and after electroacupuncture (EA) at ST-36 (hind limb) or ST-25 (abdomen). EA at ST-36 significantly increased gastric motility and decreased the ratio of low frequency (LF)/high frequency (HF) of the HRV analysis. In contrast, EA at ST-25 significantly inhibited gastric motility and increased LF/HF ratio. There was a significant correlation observed between the changes of gastric motility and LF/HF ratio in response to EA. It is suggested that the stimulatory effect of EA at ST-36 on gastric motility is associated with its stimulatory effect on vagal activity. The inhibitory effect of EA at ST-25 on gastric motility is associated with its stimulatory effect on the sympathetic nerve activity.
为阐明针刺对胃运动功能的位点特异性作用机制，我们在清醒大鼠中研究了同步记录胃动力和心电图（ECG）以进行心率变异性（HRV）分析。在电针（EA）刺激位于后肢的足三里（ST-36）或位于腹部的天枢（ST-25）之前、期间和之后记录胃动力和心电图。电针刺激ST-36可显著增加胃动力，并降低HRV分析中的低频（LF）/高频（HF）比值。相比之下，电针刺激ST-25则显著抑制胃动力并增加LF/HF比值。观察到电针刺激后胃动力变化与LF/HF比值之间存在显著相关性。提示电针刺激ST-36对胃动力的刺激作用与其对迷走神经活动的刺激作用有关。电针刺激ST-25对胃动力的抑制作用与其对交感神经活动的刺激作用有关。
