羟基脲对前循环型布氏锥虫的影响：实现同步生长的一种非常规机制。
Effect of hydroxyurea on procyclic Trypanosoma brucei: an unconventional mechanism for achieving synchronous growth.
作者信息
Chowdhury Arnab Roy, Zhao Zhixing, Englund Paul T
机构信息
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
出版信息
Eukaryot Cell. 2008 Feb;7(2):425-8. doi: 10.1128/EC.00369-07. Epub 2007 Dec 14.
Abstract
Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G(1)/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited.
摘要
将布氏锥虫的循环前期细胞与0.2 mM羟基脲同步化。细胞并未停滞在G(1)/S边界，而是经历一轮复制并在S期接近结束时停滞。线粒体基因组（动质体DNA网络）进行了复制，形成了两个子代网络，但微小环间隙的修复受到抑制。
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