mRNA剪接的全局分析
Global analysis of mRNA splicing.
作者信息
Moore Michael J, Silver Pamela A
机构信息
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
RNA. 2008 Feb;14(2):197-203. doi: 10.1261/rna.868008. Epub 2007 Dec 14.
Abstract
Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with broad roles in development and disease. Systems-wide experimental methods have started to define how global splicing regulation shapes complex biological properties and pathways. Here, we review these approaches, describe recent insights they have yielded, and discuss avenues of future investigation.
摘要
可变mRNA剪接是真核细胞中转录本多样性的丰富来源，在发育和疾病中发挥着广泛作用。全系统实验方法已开始明确全局剪接调控如何塑造复杂的生物学特性和通路。在此，我们综述这些方法，描述它们最近获得的见解，并讨论未来的研究方向。
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