软骨膜在胎儿骨骼发育中的作用。

The role of the perichondrium in fetal bone development.

作者信息

Kronenberg Henry M

机构信息

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

出版信息

Ann N Y Acad Sci. 2007 Nov;1116:59-64. doi: 10.1196/annals.1402.059.

DOI:10.1196/annals.1402.059

PMID:18083921

Abstract

Most cells in mesenchymal condensations that form endochondral bone become chondrocytes; cells at the outer edges of the condensations, however, become perichondrial cells with distinct properties and functions. Some perichondrial cells become osteoblasts that populate both the future cortical and trabecular bone; others probably become chondrocytes. Perichondrial cells both send signals to the underlying growth cartilage and receive signals from the cartilage. Here I illustrate briefly examples of the complicated interactions between the perichondrium and the underlying growth cartilage.

摘要

形成软骨内成骨的间充质凝缩物中的大多数细胞会变成软骨细胞；然而，凝缩物外缘的细胞会变成具有独特特性和功能的软骨膜细胞。一些软骨膜细胞会变成成骨细胞，这些成骨细胞会分布在未来的皮质骨和小梁骨中；其他的可能会变成软骨细胞。软骨膜细胞既向下方的生长软骨发送信号，也从软骨接收信号。在此，我简要举例说明软骨膜与下方生长软骨之间复杂的相互作用。