Scortti M, Prieto C, Alvarez E, Simarro I, Castro J M
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain.
Vet Rec. 2007 Dec 15;161(24):809-13.
This study was designed to evaluate the efficacy of an inactivated vaccine based on a European-type strain of porcine reproductive and respiratory syndrome virus (PRRSV) against the reproductive form of the syndrome in breeding gilts, and any congenital disease in their piglets. Five gilts were vaccinated twice, following the manufacturer's instructions, before they were inseminated. Nine additional gilts remained unvaccinated and served as positive (five gilts) and negative (four gilts) controls. A European wild-type strain genetically divergent from the vaccine strain was used to challenge the five vaccinated and five unvaccinated positive control gilts at 90 days' gestation. The vaccination of the five seronegative gilts did not produce any clinical signs or adverse reactions. However, the vaccine failed to prevent the clinical signs associated with PRRSV infection, viraemia after the challenge and transplacental infection of their piglets. The reproductive performance of the vaccinated gilts was similar to that of the unvaccinated positive controls, and there were no statistically significant differences in most of the parameters tested. However, the preweaning mortality of the piglets born to the vaccinated gilts was significantly lower than that of the piglets born to the positive control gilts.
本研究旨在评估一种基于欧洲型猪繁殖与呼吸综合征病毒（PRRSV）毒株的灭活疫苗对繁殖后备母猪繁殖型综合征以及其所产仔猪先天性疾病的预防效果。五头后备母猪在配种前按照制造商说明进行了两次疫苗接种。另外九头后备母猪未接种疫苗，作为阳性（五头）和阴性（四头）对照。在妊娠90天时，使用一种与疫苗毒株基因不同的欧洲野生型毒株对五头接种疫苗和五头未接种疫苗的阳性对照后备母猪进行攻毒。五头血清阴性的后备母猪接种疫苗后未出现任何临床症状或不良反应。然而，该疫苗未能预防与PRRSV感染相关的临床症状、攻毒后的病毒血症以及仔猪的经胎盘感染。接种疫苗的后备母猪的繁殖性能与未接种疫苗的阳性对照相似，在大多数检测参数上没有统计学显著差异。然而，接种疫苗的后备母猪所产仔猪的断奶前死亡率显著低于阳性对照后备母猪所产仔猪。
