Khomenko A G, Omarov T O, Kaminskaia G O, Blonskaia G Iu, Lovacheva O V
Klin Med (Mosk). 1991 Nov;69(11):43-6.
PGE and PGF2 alpha were measured by radioimmunoassay in bronchoalveolar lavage fluid obtained from the affected and contralateral lung of 86 patients with different forms of pulmonary tuberculosis. The findings were correlated with parameters of external respiration. Bronchial obstruction (BO) was found to entail lower values of PGE in the intact lung though higher PGE2 alpha levels near the focus. To normalize the proportion PGE/PGF2 alpha in the respiratory tracts, 24 tuberculous patients with BO received adjuvant ultrasound inhalations of PGE2 (prostenon). The course of 10 daily procedures produced positive shifts in bronchial patency in 3/4 of the patients. This positive trend was still demonstrable two months later. Prostenon anti-BO effect proved the highest in new-onset tuberculosis, in tuberculosis-induced intoxication and in moderate BO.
采用放射免疫分析法，对86例不同类型肺结核患者患侧肺和对侧肺支气管肺泡灌洗液体中的前列腺素E（PGE）和前列腺素F2α（PGF2α）进行了检测。检测结果与肺外呼吸参数相关联。结果发现，支气管阻塞（BO）会使健侧肺中的PGE值降低，而在病灶附近的PGE2α水平升高。为使呼吸道中PGE/PGF2α的比例正常化，24例患有支气管阻塞的肺结核患者接受了PGE2（前列地尔）辅助超声雾化吸入治疗。连续10天的治疗疗程使3/4的患者支气管通畅情况出现积极变化。两个月后，这种积极趋势仍然明显。前列地尔的抗支气管阻塞作用在新发结核病、结核中毒和中度支气管阻塞患者中效果最为显著。
