Streich Nikolaus A, Gotterbarm Tobias, Jung Martin, Schneider Ulrich, Heisel Christian
Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.
Int Orthop. 2009 Feb;33(1):77-82. doi: 10.1007/s00264-007-0477-8. Epub 2007 Dec 15.
The aim of this study was to determine the diagnostic value of systemic biochemical markers of bone turnover in aseptic loosening in hip arthroplasty, namely the urine levels of three bone resorption peptides - crosslinked n-telopeptides (NTX), c-telopeptides (CTX I) and deoxypyridinoline (DPD). We compared 52 patients with surgically proven component loosening with 52 patients without clinical or radiological signs of endoprosthetic loosening and 52 healthy individuals. All three markers were measured using commercially available enzyme-linked immunoassays. We found significantly increased levels of DPD in the loosening group (p < 0.05), but there was no significant difference between the loosening group and the two reference groups for the other two markers tested. Our data suggest that DPD can be used as an additional tool in the diagnosis of aseptic loosening in hip arthroplasty but CTX I and NTX have no predictive value in this context.
本研究的目的是确定骨代谢的全身生化标志物在髋关节置换术无菌性松动中的诊断价值,即三种骨吸收肽——交联N-端肽(NTX)、C-端肽(CTX I)和脱氧吡啶啉(DPD)的尿液水平。我们将52例经手术证实假体松动的患者与52例无临床或影像学假体松动迹象的患者以及52名健康个体进行了比较。所有三种标志物均使用市售的酶联免疫分析法进行测量。我们发现松动组中DPD水平显著升高(p < 0.05),但在另外两种检测标志物方面,松动组与两个参照组之间没有显著差异。我们的数据表明,DPD可作为诊断髋关节置换术无菌性松动的辅助工具,但CTX I和NTX在此情况下没有预测价值。