Pierlovisi-Lavaivre M, Michel B, Sebban C, Tesolin B, Chave B, Sambuc R, Melac M, Gastaut J L, Poitrenaud J, Millet Y
Laboratoire d'explorations fonctionnelles du système nerveux, CHU Timone, Marseille, France.
Neurophysiol Clin. 1991 Dec;21(5-6):411-23. doi: 10.1016/s0987-7053(05)80332-6.
One study was performed in 12 patients with presenile Alzheimer's disease (group I), the other one in 16 patients with mild senile dementia of Alzheimer type (group II). In each study, patients were divided into two randomized parallel groups, one receiving placebo, the other piracetam (9 g daily in group I piracetam and 2.4 g daily in group II piracetam) during three months, piracetam induced a decrease in EEG power on the 2-6 Hz range (group I piracetam), 3-5 Hz and 7 Hz (group II piracetam) and an increase of EEG power in the 9-11 Hz range (group I piracetam) and in the 10 Hz and 13 Hz frequencies (group II piracetam). There was also a significant improvement in the Trail Making Test part A in group II piracetam. Correlations between decreased EEG low frequency components and improvement in some psychometric tests were found significant in the two groups. It seems that the main effect of piracetam was to induce increased alertness. The same results were found in both studies; the good reproducibility suggests that EEG spectral analysis is a reliable tool in the assessment of psychotropic drug effects.
一项研究针对12例早老性阿尔茨海默病患者（第一组）进行，另一项研究针对16例轻度阿尔茨海默型老年痴呆患者（第二组）进行。在每项研究中，患者被随机分为两个平行组，一组服用安慰剂，另一组服用吡拉西坦（第一组吡拉西坦每日9克，第二组吡拉西坦每日2.4克），为期三个月。吡拉西坦使2 - 6赫兹范围（第一组吡拉西坦）、3 - 5赫兹和7赫兹（第二组吡拉西坦）的脑电图功率降低，使9 - 11赫兹范围（第一组吡拉西坦）以及10赫兹和13赫兹频率（第二组吡拉西坦）的脑电图功率增加。第二组吡拉西坦在连线测验A部分也有显著改善。在两组中，脑电图低频成分降低与一些心理测量测试改善之间的相关性显著。似乎吡拉西坦的主要作用是提高警觉性。两项研究都得到了相同的结果；良好的可重复性表明脑电图频谱分析是评估精神药物作用的可靠工具。
