Nikkilä E A, Huttunen J K, Ehnholm C
Ann Clin Res. 1976 Feb;8(1):63-7.
A subnormal activity of postheparin plasma hepatic lipase was demonstrated in nine of 16 patients with familial type II hypercholesterolemia. On the other hand, in patients with combined hyperlipidemia (type II b) the hepatic lipase activity was mostly in upper normal range. The postheparin plasma lipoprotein lipase activity was normal in both patient groups. It is suggested that the low hepatic lipase activity may have a role in the patholgenesis of one form of familial hypercholesterolemia.
在16例家族性II型高胆固醇血症患者中，有9例显示肝素后血浆肝脂酶活性低于正常。另一方面，在混合型高脂血症（II b型）患者中，肝脂酶活性大多在正常上限范围内。两组患者的肝素后血浆脂蛋白脂酶活性均正常。提示肝脂酶活性降低可能在某一型家族性高胆固醇血症的发病机制中起作用。
