Bellec S, Baccaïni B, Goubin A, Rudant J, Ripert M, Hémon D, Clavel J
INSERM, U754, Hôpital Paul Brousse, F-94807 Villejuif, France.
Br J Cancer. 2008 Jan 15;98(1):225-31. doi: 10.1038/sj.bjc.6604141. Epub 2007 Dec 18.
In a national study, we investigated the incidence of childhood leukaemia (CL) over a 14-year period in France in relation to several measures based on the proportion of individuals who changed address between the last two national censuses. A positive association was found with the proportion of migrants who came from a distant place. The further the migrants came, the higher was the incidence of leukaemia, particularly among children aged 0-4 years in 'isolated' communes at the time of diagnosis (RR=1.4, 95% CI: 1.1,1.8 in the highest category of migration distance). Although the role of the population density was less obvious, a more marked association was found above a certain threshold. No association with the proportion of commuters was observed.
在一项全国性研究中,我们调查了法国14年间儿童白血病(CL)的发病率,该发病率与基于两次全国人口普查之间地址变更个体比例的多项指标相关。研究发现,来自远方的移民比例与之呈正相关。移民来源地越远,白血病发病率越高,尤其是在诊断时处于“孤立”公社的0至4岁儿童中(在迁移距离最高类别中,相对危险度=1.4,95%置信区间:1.1,1.8)。虽然人口密度的作用不太明显,但在某个阈值以上发现了更显著的关联。未观察到与通勤者比例的关联。