[Association of microalbuminuria and von Willebrand factor with metabolic syndrome in hypertensive patients].

OBJECTIVE

To compare the difference of microalbuminuria (MAU) and von Willebrand factor (vWF) between essential hypertensives and hypertensive patients with metabolic syndrome (MS), and to explore the association of these factors with MS.

METHODS

According to the new definition of MS by International Diabetes Federation (IDF) for 2005, 133 consecutive essential hypertensives were divided into two groups: hypertensive patients with metabolic syndrome (EH-MS group, n=97), and essential hypertensives (EH group, n=36). Biochemistry assay, plasma vWF, 24 hours urine albumin excretion (UAE) and morning urine albumin/creatinine ratio (ACR) were measured. The association of MAU and vWF with MS was analysed.

RESULTS

Waist circumference, body mass index, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), plasma vWF and UAE were increased(P<0.05 or P<0.01, respectively), while high density lipoprotein cholesterol (HDL-C) was decreased (P<0.01) in EH-MS group, as compared with those in EH group. UAE was positively correlated with ACR (r=0.707, P<0.01). vWF was not correlated with UAE or ACR (r=0.079 and 0.052,P>0.05, respectively). Logistic regression showed HDL-C, TG, LDL-C,vWF and UAE were associated with the development of MS in hypertensive patients (standardized coefficients: -0.825, 0.63, 0.339, 0.331, 0.371,P<0.05 or P<0.01, respectively).

CONCLUSION

Compared with essential hypertensives, the hypertensive patients with MS had more MAU and serious endothelial dysfunction. UAE was correlated significantly with ACR. vWF and UAE were associated with the development of MS in patients with hypertension.